Structure of PDB 7w72 Chain U Binding Site BS01

Receptor Information
>7w72 Chain U (length=420) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAAPLVLVLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRVVEGLSL
LDLGVSPYSGAVFHETPLIIYLFHFLIDYAELVFMITDALTAIALYFAIQ
DFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYT
ILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLF
VPGLLYLLQRQYIPVKMKSKAFWIFSWEYAMMYVGSLVVIICLSFFLLSS
WDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFY
TIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYR
FLRNIFVLTCIIIVCSLLFPVLWHLWIYAGSANSNFFYAITLTFNVGQIL
LISDYFYAFLRREYYLTHGL
Ligand information
Ligand ID8JY
InChIInChI=1S/C28H47O13P/c1-4-7-10-13-16-22(30)40-27-25(33)23(31)24(32)26(34)28(27)41-42(35,36)38-19-20(18-37-17-14-11-8-5-2)39-21(29)15-12-9-6-3/h20,31-34H,4-19H2,1-3H3,(H,35,36)/t20-/m1/s1
InChIKeyJZBYPPGRAPDSFI-HXUWFJFHSA-N
SMILES
SoftwareSMILES
CACTVS 3.385CCCCCCOC[CH](CO[P](O)(=O)Oc1c(O)c(O)c(O)c(O)c1OC(=O)CCCCCC)OC(=O)CCCCC
CACTVS 3.385CCCCCCOC[C@H](CO[P](O)(=O)Oc1c(O)c(O)c(O)c(O)c1OC(=O)CCCCCC)OC(=O)CCCCC
OpenEye OEToolkits 2.0.7CCCCCCC(=O)Oc1c(c(c(c(c1OP(=O)(O)OCC(COCCCCCC)OC(=O)CCCCC)O)O)O)O
OpenEye OEToolkits 2.0.7CCCCCCC(=O)Oc1c(c(c(c(c1OP(=O)(O)OC[C@@H](COCCCCCC)OC(=O)CCCCC)O)O)O)O
FormulaC28 H47 O13 P
Name[2-[[(2~{R})-2-hexanoyloxy-3-[(~{E})-hex-3-enoxy]propoxy]-oxidanyl-phosphoryl]oxy-3,4,5,6-tetrakis(oxidanyl)phenyl] (2~{E},4~{E})-hepta-2,4-dienoate
ChEMBL
DrugBank
ZINC
PDB chain7w72 Chain U Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7w72 Structure of human glycosylphosphatidylinositol transamidase.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		N383 N385 F386 A389
Binding residue
(residue number reindexed from 1)		N383 N385 F386 A389
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0034235 GPI anchor binding
Biological Process
GO:0006506 GPI anchor biosynthetic process
GO:0016255 attachment of GPI anchor to protein
GO:0046425 regulation of receptor signaling pathway via JAK-STAT
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0042765 GPI-anchor transamidase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7w72, PDBe:7w72, PDBj:7w72
PDBsum7w72
PubMed35165458
UniProtQ9H490|PIGU_HUMAN Phosphatidylinositol glycan anchor biosynthesis class U protein (Gene Name=PIGU)

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