Structure of PDB 7vm6 Chain U Binding Site BS01

Receptor Information
>7vm6 Chain U (length=247) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFID
YPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIAL
LKIRSKEGRCAQPSRTIQTIALPSMYNDPQFGTSCEITGFGKEQSTDYLY
PEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGG
PLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKE
Ligand information
Ligand ID7R8
InChIInChI=1S/C11H10N2O/c12-11(13)9-2-1-8-6-10(14)4-3-7(8)5-9/h1-6,14H,(H3,12,13)
InChIKeyULKSSXOMKDEKPC-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7c1cc(cc2c1cc(cc2)O)C(=N)N
CACTVS 3.385NC(=N)c1ccc2cc(O)ccc2c1
OpenEye OEToolkits 2.0.7[H]/N=C(\c1ccc2cc(ccc2c1)O)/N
FormulaC11 H10 N2 O
Name6-oxidanylnaphthalene-2-carboximidamide
ChEMBL
DrugBank
ZINCZINC000002516802
PDB chain7vm6 Chain U Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7vm6 Structural study of the uPA-nafamostat complex reveals a covalent inhibitory mechanism of nafamostat.
Resolution1.79 Å
Binding residue
(original residue number in PDB)		D189 S190 Q192 W215 G219 C220 E244
Binding residue
(residue number reindexed from 1)		D192 S193 Q195 W218 G221 C222 E247
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:7vm6, PDBe:7vm6, PDBj:7vm6
PDBsum7vm6
PubMed36039386
UniProtP00749|UROK_HUMAN Urokinase-type plasminogen activator (Gene Name=PLAU)

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