Structure of PDB 7q0p Chain U Binding Site BS01

Receptor Information
>7q0p Chain U (length=141) Species: 237561 (Candida albicans SC5314) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PGVSVRDVPAQDFINAYAQFLQRQGKLEVPGYVDIVKTSAGNDLPPQEAE
TWFYKRAASIARHIYLRKQVGVGALNKLYGGAKNRGFRPHKHVDASGSIN
RKCVQALQKIGVLEISPKGGRRISENGQRDLDRIAAQTLEE
Ligand information
>7q0p Chain A (length=1692) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguauacuuggauaaccgugguaau
ucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauu
uauuagauaaaaauuugaugauucauaauaacuuuucgaaucgcauggcc
uugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugg
uaggauaguggccuaccaugguuucaacggguaacggggaauaaggguuc
gauuccggagagggagccugagaaacggcuaccacauccaaggaaggcag
caggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaau
aacgauacagguuguaauuggaaugaguacaauguaaauaccuuaacgag
gaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuc
caaaagcguauauuaaaguuguugcaguuaaaaagcucguaguugaaccu
ugggcuuggcuggccgguccuggacccagccgagccuuuccuucuggcca
ggacuuuuacuuugaaaaaauuagaguguucaaagcaggccuuugcucga
auauauuagcauggaauaauagaauaggacguuaugguucuauuuuguug
guuucuaggaccaucguaaugauuaauagggacggucggggguaucagua
uucaguugucagaggugaaauucuuggauuuacugaagacuaacuacugc
gaaagcauuuaccaaggacguuuucauuaaucaagaacgaaaguuagggg
aucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgac
uagggaucgguuguuguucuuuuauugacgcaaucggcaccuuacgagaa
aucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuua
aaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuu
gacucaacacggggaaacucaccagguccagacacaauaaggauugacag
auugagagcucuuucuugauuuugugggugguggugcauggccguucuua
guugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaa
ccuacuaaauagugcugcuagcauuugcugguauagucacuucuuagagg
gacuaucgauuucaagucgauggaaguuugaggcaauaacaggucuguga
ugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcg
aguauaagccuuggccgagaggucugggaaaucuugugaaacuccgucgu
gcuggggauagagcauuguaauuguugcucuucaacgaggaauuccuagu
aagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacaca
ccgcccgucgcuacuaccgauugaauggcuuagugaggccuccggauugg
uuuagggaaccgagaagcuggucaaacuuggucauuuagaggaaguaaaa
gucguaacaagguuuccguaggugaaccugcggaaggaucau
...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<.........<<.....<..<<<....
.>>>..>......>>........<<<<<..<<....>>..>>>>><...<
<<<<<....................>>>>>>.....>...<<<<..<<<.
....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<
<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>
....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>
>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>...
..<<<<...<..>...>>>>......<<..<...........>..>>...
......<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>
>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<...
.<<<<<<<<<<<<............>>>>>>>>>>>>....<<<<<..>>
>>>...<<<<<.<<.......<<...<.......>..<<<....>>>...
.>>......>>.>>..>>>.........<<<..<<<<<<<<<........
.....>>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..
<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<
....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<.
..<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<
.<<<..<<<<<<<<..<<........>>.>>>>>>>>..>>>...<<..)
)>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>.
.)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<
<........>>..........<<<<<.<....<<<<<........<<.<<
<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....
<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.
<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>
....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>
>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......
<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>..
....<....<<<<<<..........>>>>>>....>.....>>>>>>...
.<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>..
..<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<
<.......>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...
>.>>...>.....<<<<<<<<<<..>>>>>>>>>>.......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7q0p E-site drug specificity of the human pathogen Candida albicans ribosome.
Resolution2.77 Å
Binding residue
(original residue number in PDB)
P2 G3 R7 A11 I15 V37 K38 T39 A41 N43 D44 L45 Q48 R57 S60 R63 H64 R68 K69 V73 G74 K78 G81 K84 N85 R86 G87 F88 R89 P90 H91 K92 H93 S97 G98 S99 R102 Q106 G121 R122 E126 Q129 D133
Binding residue
(residue number reindexed from 1)
P1 G2 R6 A10 I14 V36 K37 T38 A40 N42 D43 L44 Q47 R56 S59 R62 H63 R67 K68 V72 G73 K77 G80 K83 N84 R85 G86 F87 R88 P89 H90 K91 H92 S96 G97 S98 R101 Q105 G120 R121 E125 Q128 D132
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7q0p, PDBe:7q0p, PDBj:7q0p
PDBsum7q0p
PubMed35613268
UniProtA0A1D8PK61|RS19A_CANAL Small ribosomal subunit protein eS19 (Gene Name=RPS19A)

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