Structure of PDB 7pfu Chain U Binding Site BS01

Receptor Information
>7pfu Chain U (length=75) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLK
SLVSKGTLVQTKGTGASGSFKLNKK
Ligand information
>7pfu Chain I (length=354) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggccgccactggccactggagaatcccggtgccgaggccgctcaattggt
cgtagacagctctagcaccgcttaaacgcacgtacgcgctgtcccccgcg
ttttaaccgccaaggggattactccctagtctccaggcacgtgtcacata
tatacatcctgtgcatgtaagtgcatgggccgccactggccactggagaa
tcccggtgccgaggccgctcaattggtcgtagacagctctagcaccgctt
aaacgcacgtacgcgctgtcccccgcgttttaaccgccaaggggattact
ccctagtctccaggcacgtgtcacatatatacatcctgtgcatgtaagtg
catg
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7pfu Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory.
Resolution5.0 Å
Binding residue
(original residue number in PDB)		L58 K62 K80 T98 G99 A100 S101
Binding residue
(residue number reindexed from 1)		L24 K28 K46 T64 G65 A66 S67
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031490 chromatin DNA binding
GO:0031492 nucleosomal DNA binding
GO:0042826 histone deacetylase binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006357 regulation of transcription by RNA polymerase II
GO:0030261 chromosome condensation
GO:0045910 negative regulation of DNA recombination
Cellular Component
GO:0000786 nucleosome
GO:0000791 euchromatin
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005694 chromosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7pfu, PDBe:7pfu, PDBj:7pfu
PDBsum7pfu
PubMed35581345
UniProtP10412|H14_HUMAN Histone H1.4 (Gene Name=H1-4)

[Back to BioLiP]