Structure of PDB 7pf2 Chain U Binding Site BS01

Receptor Information
>7pf2 Chain U (length=75) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLK
SLVSKGTLVQTKGTGASGSFKLNKK
Ligand information
>7pf2 Chain I (length=339) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cactggccgcctggagaatcccggtgccgaggccgctcaattggtcgtag
acagctctagcaccgcttaaacgcacgtacgcgctgtcccccgcgtttta
accgccaaggggattactccctagtctccaggcacgtgtcagatatatac
atcctgtcatgtaagtatcgcgcactggccgcctggagaatcccggtgcc
gaggccgctcaattggtcgtagacagctctagcaccgcttaaacgcacgt
acgcgctgtcccccgcgttttaaccgccaaggggattactccctagtctc
caggcacgtgtcagatatatacatcctgtcatgtaagta
Receptor-Ligand Complex Structure
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PDB7pf2 Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory.
Resolution5.1 Å
Binding residue
(original residue number in PDB)		K80 T98 A100 S101
Binding residue
(residue number reindexed from 1)		K46 T64 A66 S67
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031490 chromatin DNA binding
GO:0031492 nucleosomal DNA binding
GO:0042826 histone deacetylase binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006357 regulation of transcription by RNA polymerase II
GO:0030261 chromosome condensation
GO:0045910 negative regulation of DNA recombination
Cellular Component
GO:0000786 nucleosome
GO:0000791 euchromatin
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pf2, PDBe:7pf2, PDBj:7pf2
PDBsum7pf2
PubMed35581345
UniProtP10412|H14_HUMAN Histone H1.4 (Gene Name=H1-4)

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