Structure of PDB 7p7q Chain U Binding Site BS01

Receptor Information

>7p7q Chain U (length=101) Species: 1351 (Enterococcus faecalis)

MYAIIKTGGKQVKVEVGQAIYVEKLNVEAGEKVVFDEVILVGGESTKVGA
PTVAGATVEGTVEKHGKQKKVVTFQYKPKKHSHRKQGHRQPYTKVMIEAI
N

Ligand information

>7p7q Chain A (length=2901)

uuaagugaauaagggcgcacgguggaugccuuggcacuaggagccgauga
aggacgggacuaacaccgauaugcuuuggggagcuguaaguaagcuauga
uccagagauuuccgaaugggggaacccaauaucuuuuauaggauauuacu
uuucagugaauacauagcugauuagagguagacgcagagaacugaaacau
cuuaguaccugcaggaagagaaagaaaauucgauucccugaguagcggcg
agcgaaacgggaagagcccaaaccaacaagcuuguugggguuguaggacu
ccgauaugguagucuguuaguauaguugaaggauuuggaaaauuccgcua
aagagggugaaagccccguagacgaaaugcugacaacaccuaggaggauc
cugaguacggcggaacacgagaaauuccgucggaauccgcggggaccauc
ccgcaaggcuaaauacucccuagugaccgauagugaaccaguaccgugag
ggaaaggugaaaagcaccccggaaggggagugaaauagauccugaaaccg
ugugccuacaacaagucaaagcucguuaaugagugauggcgugccuuuug
uagaaugaaccggcgaguuacgauugcaugcgagguuaagucgaagagac
ggagccgcagcgaaagcgagucugaauagggcgaaugaguauguagucgu
agacccgaaaccaugugaucuacccauguccagguugaaggugcgguaaa
acgcacuggaggaccgaacccacguacguugaaaagugcggggaugaggu
guggguagcggagaaauuccaaacgaacuuggagauagcugguucucucc
gaaauagcuuuagggcuagccucggaauugagaaugauggagguagagca
cuguuuggacuaggggcccaucucggguuaccgaauucagauaaacuccg
aaugccauucauuuauauccgggagucagacugcgagugauaagauccgu
agucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauaug
uuaaguggaaaaggaugugggguugcacagacaacuaggauguuggcuua
gaagcagccaccauuuaaagagugcguaauagcucacuagucgagugacc
cugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggacua
caccauuagguguagugguaggagagcguucuaagggcguugaaggucga
ucgugaggacggcuggagcgcuuagaagugagaaugccgguaugaguagc
gaaagacaggugagaauccuguccaccguaugacuaagguuuccugggga
aggcucguccgcccaggguuagucgggaccuaagccgaggccgauaggcg
uaggcgauggacaacagguugauauuccuguaccaguuguuuuuguuuga
gcaauggagggacgcaguaggcuaaggaaugcaugcgauuggaagugcau
guccaagcaaugagucuugaguagaguuaaaugcuuuacucuuuaaggac
aaguugugacggggagcgaaauaguagcgaaguuccugacgucacacugc
caagaaaagcuucuagugagaaaacaacugcccguaccguaaaccgacac
agguagucgaggagaguauccuaaggugagcgagcgaacucucguuaagg
aacucggcaaaaugaccccguaacuucgggagaaggggugcugacuucgg
ucagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucu
cugcaaaaucguaagaugaaguauaggggcugacgccugcccggugcugg
aagguuaagaggauggguuagcuucggcgaagcucagaauugaagcccca
guaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugu
cggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucuc
aacgagagacucggugaaauuuuaguaccugugaagaugcagguuacccg
cgacaggacggaaagaccccauggagcuuuacuguaguuugauauugagu
guuuguaccacauguacaggauagguaggagccgaugagaccggaacgcu
aguuucggaggaggcgcuggugggauacuacccuuguguuaugaacccuc
uaacccgcaccacuaaucguggugggagacagugucagaugggcaguuug
acuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccu
cagaaugguuggaaaucauucgaagaguguaaaggcagaagggagcuuga
cugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccg
gugguuccgcauggaagggccaucgcucaacggauaaaagcuacccuggg
gauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggc
accucgaugucggcucgucgcauccuggggcuguagucggucccaagggu
ugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgu
gagacaguucggucccuauccgucgcgggcguuggaaauuugagaggagc
uguccuuaguacgagaggaccgggauggacuuaccgcugguguaccaguu
guucugccaagggcauugcuggguagcuauguagggaagggauaaacgcu
gaaagcaucuaagugugaagcccaccucaagaugagauuucccauuucuu
uaagaaaguaagaccccugagagaugaucagguagauagguuggaagugg
aaggcuagugauaguuggagcggaccaauacuaaucggucgaggacuuaa
c

<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<.....
.<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....
>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<
..<<<<<.........>>>>>..>>.>>....<<<<<......<<....>
>.......>>>>.>.........<<....>>..<<<<<......<<....
.>>.....>>>>>..(((....<<<<<<<..>>>>>>>......<<<<<<
<<...<.<<<.<<.<<<<<<<<<.<<<...<<<.<......>.>>>((..
....<<<.....))>>>...>>>...>>>>>>>>>>>>>>>.>>>>..>>
>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>
>>>>..)))......]].>>>>>>>.]]...............<<....>
>....]].........<<<<....>>>>..................>>>>
>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<....
....>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>
...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>
>..<<.<...<<<.<<.....<<<<<<<<<..<<<....<<<<<<.....
.>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>
>>>>>>...<<<.....>>>......>>.>>>......>.>>..<<<<<<
....<<<<<....>>>>><<<<<<<<.<...<<<<<<<<<.....<<<..
.<<<<<<<<...<<.<<<<.....>>>>..>>...>>>>>>>>..>>.>.
....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>
>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<
<...........<<..<<<<<<<<<........<<<<<.<<...<<<<..
.....>>>>...>>.........<<......>>...>>>>>....>>>>>
>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<
<<<<....>>>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.
<<....>>.>>>>>...>>.>>>>>>>........>>>>>>.......<<
....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<..
.<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>.
..>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<......
<<...<<<<....<<<<..<<...<<<<<.<<<<<<...(((....>>>>
>><<..<<<<<..<<<<.<<<<<<<<<.....>>>>>>>>>.....>>>>
..>>>>>...>>...<<.........>>....>>>>>....>>...>>>>
.........>>>>..>>..>>>>>>>>>>>>>>>.>>>.....<<.....
.>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.
..............<<<<<...............>>>>><<<<<<....>
>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<
<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<
..<<<...<<...<<<<<..<<....>>...>>>>>...>>...>>>>>>
>>..>>>>><<<<<<.......>>>>>>........<...........<<
<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.
>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<
<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.
<<<<<<<.<<<<...........<<<<<..<<<.......<<<<<<<...
.>>>>>>>....>>>............>>>>>..>>>>.>>>>>>>.>>>
....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<
<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<.
..<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...
<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<
<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>
.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>
.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.
<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<..
..>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<
<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<
<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<
...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<..
...>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<<..
..<<<<<....>>>>>...>>...>>>>>.>>>...>>>>....>>>>>>
.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7p7q Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): G8 G9 K10 Y21 E23 K24 Q68 K70 V71 T73 Q75 Y76 K77 P78 K79 K80 H81 S82 H83 R84 K85 Q86 G87 H88 R89 Q90 P91 Y92
• Binding residue (residue number reindexed from 1): G8 G9 K10 Y21 E23 K24 Q68 K70 V71 T73 Q75 Y76 K77 P78 K79 K80 H81 S82 H83 R84 K85 Q86 G87 H88 R89 Q90 P91 Y92

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7p7q, PDBe:7p7q, PDBj:7p7q
• PDBsum: 7p7q
• PubMed: 35387982
• UniProt: Q836X6|RL21_ENTFA Large ribosomal subunit protein bL21 (Gene Name=rplU)