Structure of PDB 7k5x Chain U Binding Site BS01

Receptor Information
>7k5x Chain U (length=74) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKVGENADSQIKLSIK
RLVTTGVLKQTKGVGASGSFRLAK
Ligand information
>7k5x Chain I (length=197) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gggctggaccctatacgcggccgccctggagaatcccggtgccgaggccg
ctcaattggtcgtagacagctctagcaccgcttaaacgcacgtacgcgct
gtcccccgcgttttaaccgccaaggggattactccctagtctccaggcac
gtgtcagatatatacatcctgtgcatgtattgaacagcgaccacccc
Receptor-Ligand Complex Structure
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PDB7k5x Distinct Structures and Dynamics of Chromatosomes with Different Human Linker Histone Isoforms.
Resolution2.93 Å
Binding residue
(original residue number in PDB)		H24 Y27 S45 Q47 Q66 R73 K84 S91
Binding residue
(residue number reindexed from 1)		H2 Y5 S23 Q25 Q44 R51 K62 S69
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003680 minor groove of adenine-thymine-rich DNA binding
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031490 chromatin DNA binding
GO:0031491 nucleosome binding
GO:0031492 nucleosomal DNA binding
Biological Process
GO:0006334 nucleosome assembly
GO:0030261 chromosome condensation
GO:0031507 heterochromatin formation
GO:0045910 negative regulation of DNA recombination
GO:2000679 positive regulation of transcription regulatory region DNA binding
Cellular Component
GO:0000785 chromatin
GO:0000786 nucleosome
GO:0000791 euchromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005794 Golgi apparatus
GO:0015629 actin cytoskeleton
GO:0016604 nuclear body
GO:0017053 transcription repressor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7k5x, PDBe:7k5x, PDBj:7k5x
PDBsum7k5x
PubMed33238161
UniProtP07305|H10_HUMAN Histone H1.0 (Gene Name=H1-0)

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