Structure of PDB 7alp Chain U Binding Site BS01

Receptor Information
>7alp Chain U (length=1935) Species: 1173018 (Phlebovirus WCH/97/HN/China/2011) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNLEVLCGRINVENGLSLGEPGLYDQIYDRPGLPDLDVTVDATGVTVDLI
TIQLSEAYKINHDFTFSGLSKTTDRRLSEVFPITHDGSDGMTPDVIHTRL
DGTIVVVEFTTTRSHNIGGLEAAYRTKIEKYRDPISRRVDIMENPRVFFG
VIVVSSGGVLSNMPLTQDEAEELMYRFCIANEIYTKARQKSEEELEAISR
ALSFFSLFEPNIERVEGTFPNSEIEMLEQFLSTPADVDFITKTLKAKEVE
AYADLCDSHYLKPEKTIQERLEINRCEAIDKTQDLLAGLHARSNKQTSLN
RGTVKLPPWLPKPSSESIDIKTDSGFGSLMDHGAYGELWAKCLLDVSLGN
VEGVVSDPAKELDIKEAKITYRRFKPALSSSARQEFSLQGDALSPFLDVE
DIGDFLTFNNLLADSRYGDESVQRAVSILLEKASAMQDTELTHALNDSFK
RNLSSNVVQWSLWVSCLAQELASALKQHCRAGEFIIKKLKFWPIYVIIKP
TKSSSHIFYSLGIRKADVTRRLTGRVFSETIDAGEWELTEFKSLKTCKLT
NLVNLPCTMLNSIAFWREKLGVAPWLVRKPCSELREQVGLTFLISLEDKS
KTEEIITLTRYTQMEGFVSPPMLPKPQKMLGKLDGPLRTKLQVYLLRKHL
DCMVRIASQPFSLIPREGRVEWGGTFHAISGRSTNLENMVNSWYIGYYKN
KEESTELNALGEMYKKIVEMEEDKPSSPEFLGWGDTDSPKKHEFSRSFLR
AACSSLEREIAQRHGRQWKQNLEERVLREIGTKNILDLASMKATSNFSKD
WELYSEVQTKEYHRSKLLEKMATLIEKGVMWYIDAVGQAWKAVLDDGCMR
ICLFKKNQHGGLREIYVMDANARLVQFGVETMARCVCELSPHETVANPRL
KNSIIENHGLKSARSLGPGSININSSNDAKKWNQGHYTTKLALVLCWFMP
AKFHRFIWAAISMFRRKKMMVDLRFLAHLSSPFREAMTDAFHGNREVSWM
DKGRTYIKTETGMMQGILHFTSSLLHSCVQSFYKSYFVSKLKEGYMGESI
SGVVDVIEGSDDSAIMISIRPKSDMDEVRSRFFVANLLHSVKFLNPLFGI
YSSEKSTVNTVYCVEYNSEFHFHRHLVRPTLRWIAASHQISETEALASRQ
EDYSNLLTQCLEGGASFSLTYLIQCAQLLHHYMLLGLCLHPLFGTFMGML
ISDPDPALGFFLMDNPAFAGGAGFRFNLWRACKTTDLGRKYAYYFNEIQG
KTKGDEDYRALDATSGGTLSHSVMVYWGDRKKYQALLNRMGLPEDWVEQI
DENPGVLYRRAANKKELLLKLAEKVHSPGVTSSLSKGHVVPRVVAAGVYL
LSRHCFRFSSTQKASLIKLLMMSSLNPNQERMLFPQAQEYDRVCTLLEEV
EHLTGKFVVRERNIVRSRIDLFQEPVDLRCKAEDLVSEVWFGLKRTKLGP
RLLKEEWDKLRASFAWLSTDPSETLRDGPFLSHVQFRNFIAHVDAKSRSV
RLLGAPVVTTISQVVRMNFFPGFSLEALESISILKHVLFMVLNGPYTEEY
KLEMIIEAFSTLVIPQPSEVIRKSRTMTLCLLSNSILDQIERAQSGTLGG
FSKPQKTFIRPGGGVGYKGKGVWTGVMEDTHVQILIDGDGTSNWLEEIRL
SSDARLYDVIESIRRLCDDLGINNRVASAYRGHCMVRLSGFKIKPASRTD
GCPVRIMERGFRIRELQNPDEVKMRVRGDILNLSVTIQEGRVMNILSYRP
RDTDISESAAAYLWSNRDLFSFPSCSWICLKASVLLANDRKTQGIDNRAM
GNIFRDCLEGSLRKQGLMRSKLTEMVEKNVVPLTTQELVDILEEDIDFSD
VIAVELSEGSLDIESIFDGAPILWSAEVEEFGEGVTLMDQAAITMCAIMG
KEGCRGLLTEKRCMAAIREQVRPFEDSISWVSDQF
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7alp Chain U Residue 2101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7alp Errors in the deposited SFTSV L protein structure.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		D1127 E1180
Binding residue
(residue number reindexed from 1)		D1062 E1115
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016740 transferase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication
Cellular Component
GO:0044165 host cell endoplasmic reticulum
GO:0044172 host cell endoplasmic reticulum-Golgi intermediate compartment
GO:0044177 host cell Golgi apparatus
GO:0044423 virion component

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7alp, PDBe:7alp, PDBj:7alp
PDBsum7alp
PubMed33927385
UniProtI0DF35|L_SFTS RNA-directed RNA polymerase L

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