Structure of PDB 7a5h Chain U Binding Site BS01

Receptor Information
>7a5h Chain U (length=152) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARNVVYPLYRLGGPQLRVFRTNFFIQLVRPGVAQPEDTVQFRIPMEMTRV
DLRNYLEGIYNVPVAAVRTRVQHGSNKRRDHRNVRIKKPDYKVAYVQLAH
GQTFTFPDLFPEKDESPEGSAADDLYSMLEEERQQRQSSDPRRGGVPSWF
GL
Ligand information
>7a5h Chain A (length=1457) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccccaccuuacuaccaaaccuuagccaaacc
auuuacauaaaguauaggcgauagaaauugggcgcaauagauauaguacc
gcaagggaaagaugaaaaaaccaagcauaauauagcaaggacuaaccccu
auaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaagagca
cacccgucuauguagcaaaauagugggaagauuuauagguagaggcgaca
aaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguuc
aacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguua
guccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagag
aguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaag
aaagcguucaagcucaacacaaaaaucccaaacauauaacugaacuccuc
acacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguau
aaguaacaugaaaacauucuccuccgcauaagccugcgucagcaacugac
aauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccuca
cugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaa
aggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucua
gcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacgg
ccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaau
agggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuua
accagugaaauugaccugcccgugaagaggcgggcauaacacagcaagac
gagaagacccuauggagcuuuaauuuauuaaugcaaacaccugcauuaaa
aauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguaca
ugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuuga
ccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagagu
ccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccg
auggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuac
gugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuua
uuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcg
ccuucccccguaaaugauaucaucucaacuuagauacccacacccaagaa
caggguu
<<<.......<<<<...............................<....
..>...........<<.....>>.......>>.>>.............<<
....>>.................>>>...........<<<.......>>>
...<.<........>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<...>>>.
..<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.....
..>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>>
<<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.
<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<
<<...<...................<<<.........>>>..........
..<<<......>>>..........................>...>>>>>>
........>>>>>>...<<<<<......>>>>>.........>>>>>><.
.....<<..<<<....>>><<<<..<<<<........<<<<<...>>>>>
......<<<...<<<<.......................>>>>.......
>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.
<<.........<......<<<<<<..<<<.........>>>...<<<<<<
.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>
><<<<..........>>>>........<...........<<<<<<.....
>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>
>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.
<<......<<<<.<<<<<<..<<<<<.<<<<<<<<......>>>>>>>>>
>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<....
.<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>.
...........>>>>..>>>>>>.......<<<..<.<<<<<<...<<..
.....>>...>>>>>>...>.>>.>.......<<<<<..<<<<<..<<.<
<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..
....>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>..<
<<.<<<.................>>>.>>><<<<<...<<<....>>>.>
>>>>......<<<................>>>.........<<<<.....
..>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7a5h Elongational stalling activates mitoribosome-associated quality control.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		N4 Y7 P8 L9 G32 V33 Q35 Q41 T49 R50 V51 R69 R71 Q73 H74 N77 K78 R79 R83 N84 K93 Y96
Binding residue
(residue number reindexed from 1)		N3 Y6 P7 L8 G31 V32 Q34 Q40 T48 R49 V50 R68 R70 Q72 H73 N76 K77 R78 R82 N83 K92 Y95
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0001650 fibrillar center
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:0044391 ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7a5h, PDBe:7a5h, PDBj:7a5h
PDBsum7a5h
PubMed33243891
UniProtQ16540|RM23_HUMAN Large ribosomal subunit protein uL23m (Gene Name=MRPL23)

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