Structure of PDB 6ywv Chain U Binding Site BS01

Receptor Information

>6ywv Chain U (length=138) Species: 367110 (Neurospora crassa OR74A)

SFFRITLHRSAIGLPKRTHGVLAALGLRRRNQTVFHPVEPQFAGMLMKVK
ELVRVEEVPHRLTKRELKDERKPDAGFVVEKQVRRFIPGVGVQDEVDFSK
VGAVVRDGKRAGDLGVRTRSDWEVIGKMKSVLPKVKAL

Ligand information

>6ywv Chain A (length=2529)

guaauggauauaaagcuuauguuuauauauauauauaaguauauaaagag
acuacuaccaauagcuacacuauguauuaaggagaguauaacuuaauuua
uguuuaugauagagguuaucaacauaugaacucuuagagaaauuacuuaa
uaaacgaagugaauugaaauaucuuauuaacuucaggaaaagaaaucaaa
cgagauucuaugauuagugugaacgaaaauagagcagccuauuaaaauaa
guaaaauggcuuuaaagcuguuugaauauuguggggaaccuuccucaaag
gcuaaauauaauacaugaguuacagagaaaaguaccgugagggaaagcuu
ugaaauaguaguuuuauaagcagcucaagcaauaagaaagcgagagcgua
ccuuuugcauaaugggucaccaaguuaauuuuagaugcgagcgaauuaga
ugugcauaguuaaaccgaucauuaaaauaaugaauagugucuaaaguuag
acccgaagccuggugaucuuacuauagucaggacuauaaagguccgaacg
gguuaucguugcaaagauauccgaagaacuaugguaagcgagugaaagac
aacacugacuaggauagcugguuuucugcgaaaccuauaauaguaggcaa
uuuaaguaacaucuuaguagguacagaacuuaaucucagacaagauguag
auuuucauaccuagguaugaaaugcauuuuuuuuuguauacaucgggguu
aucggugaguauguagacucggaaugacaaagaugaaucuugaauaauca
gacauagaaugauaagguuguaugucaaaagggaaacagcccagaacaag
aguuaagguuccaaaauuauuauuaagugaaauaaagaaaguuuuuauau
aagucgacaagaagaugggcuuggaagcagccauaauuuaaagaucucgu
aacagagcacuuguuaaaucuuaaaagcaucgaaaauuuaacggaucuaa
auaauauaccgaaaccuuguccauauguaacauuaguaauaauauuaaug
uuauuugaugggguagcagaacguugagugaaucuuagauuuuuuuuuua
uaacuaaauauagaugauaacucaagugagaauggugacaugaguaacaa
aaaagaguuuaagguaccuaaaagguaucuuagagucucgccuaaagcuu
auggcuacgucaaguaacggccucuaaguuuauaaucugaagauuaugac
gaugagaaaacuuugguaccaacauuuaaaagugaaaauugugcaggaag
gauaaaccguaccuagaaucugaaacaaguaagcuaguagagaauacgaa
ggcgugaaugagauaacaaucauaaaggaacucggcaaacuauaccguaa
cuuagggauaaggagagcauggaauauuguuguacgacuguuuaauuaaa
acaaagcacuuugcaaaaagacgauaagucuaaguauugagugugauuuc
auguaacgauacaacagcugucucuaugauugacucagugaaauuggaau
aacugugcagauacaguuuaccucuaguuagacgagaagacccuaugcag
cuuuacuguuacuaauuauugaauacgaaucguauuauuaaaccuuaaau
uaaggaacaauuguuagaagacaguuuaggccccauaaagaguaaauggg
ugugucuaaaauguuugcaauuuuuuauaguauauaucaaaucaucuuua
ugcuauucauggguacaguauaaaaauuuaagaaauuagguaagauuuug
uuuauagagaaauuagauguaaaaaaaaaaucuuaugagggcggauccgc
uucuaauauuuuuuuguaguuauuauuauaauaauaaucauguuuauuac
uuaaaaagcuuaauggcuuaaucuugccuuacuguuugauuaacaacaaa
ucuuacagucgcguaagcggggcauaggaucacaagauacaaaaaggaaa
gaucuuggauuuuuggaaaagcuacgcuagggauaacaggcuaauuugcg
caagaguguacaaaaugagugcgcgguuuggcaccucgaugucggcuuga
cuaauccucauggaugcagaaacuauguaggguacgacuguucgucgauu
aaaaaguuacaugagcuggguuaaauacgucgugagacaguaugguuucu
aucuucuagagggaauuagaauauaauaaggauuaaccuuuguacgaaag
gaacaugggguacuauuguuauauaacaguuuuauuaaccucugguuuac
cuguuguuuaugugccuuagggauguuaccgucacuugaguaaauacaau
agcauaagcauggcaggaaagcuaaguuagucaaaaauaagugcugaaag
cauauaggcacgaaauuuaccuuaagauauuucuuaaauauacguaagaa
aauauuacguuaauaggcuuaguuuguaaggaacuaaguacuaauuuuau
aaaaaacugaaugauuaauauaucuuaca

<<<<..<<<<<<.......<<<<<<<<<..>>>>...<<<.......<<<
<<<<<<<......<<.....<<<<<<<<<.<<<<<<.....>>.....<<
<<<<................>>>>>>....>>>>..<<....>>......
....<<<<<<.....<......>......>>>>>.>.........<<...
.>>..<<<<<<.....<<....>>....>>>>>>..<<............
...<<<<<<<<....>>>>>>>>........<<<<<..[[[[>>>>>...
>>......>>>>>>>>>.................<<....>>....>>..
.....>>>>>>>>>>.......<<<<..<<.........>>..>>>>...
<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<.......
..>>>...<......>..<<<<<.....>>>>>...>>>>>>>>>>>>>.
.<<.<..<<<<<<<....<<<<<<<<<<..<<<<<....>>.>>>...<<
<..<<<<........>>>>.>>>....>>>>>>>>>>....<<.....>>
.......>>>>>>.>..>.>>..<<<<<<....<<<<<....>>>>>..<
<<<<<<...<<<<<<.<<.....<<<......<<<<<<.<<<<<<<.<.<
..<<<<<<<<<..>>>>>>>>>>>.>>>.....>>>>.....<<<<<..>
.>>>>>>>>.>>.....>>.>.....>>.>>>>>>...>>>>>>>.....
<<<<<<.<<<......>>>.>>>>>>....<<<......>>>...<<<<<
.<<...<<<(((.....<<<<<<.....<<......<<..<<<<<<<...
.....<<<<<<.<....<<<<.......>>>>....>........<<<..
....>>>..>>>>>>......>>>>>>>.>>...........)))>>...
>>>>>>.>>>...>>>>>>><<<<..<<<<<<<<<<<<....>>>>>>>>
>>>>...>>>>....>>>>>>..<<<<<<..<<<....<<..<<..<<..
.>>..>>..>>....>>>.>>>>>>........>>>>>><......<<..
...<<<.<<<<<<<<<<<.....>>>>>>>>>>>.>>><<<<<...<<<<
<.<<........((...<<<.<<<...<<<.<<<<<<<..>>>>>>>>>>
...>>>....)).........<<<.<<..(((((..>>.>>>........
......>>>..>>......<<......>>>>>>>..<<<.....>>>..>
>>>>....<<<<....<<<<<<<<.<<.................<<....
<<..>>.....>>..............<<<<<<<<<..<<<.........
>>>..<<<<<<.......<<<<.....>>>>.......>>>>>>....<.
>.....>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....
<<<<<........>>>>>..<<<<<<<..<<<.<<...<<<<<<<.<<<<
<<..<<<<<..<<<<<.<<..<<<<<<<.>>>>>>>......<<<<....
.>>>>....>>.>>>>>...>>>>>....<<<<<<...........>>>>
.>>..<<.....<.......<<<..<<<<...>>>>..>>>.>.......
...<<<<<..>>>>>.......................<<<<<<<.....
<<<<.........>>>>.<<<<..<<<<<<<.<<<.<<.<<<<<..>>>>
>>>>>>.>>>.>>>>...<<<<<<<<<..>>>>>>>>>........>>>>
......<<<...(((>>>...>>>>>>>...<<<<..<<<.........>
>>..>>>>.<<<....>>>.>>))).......<<<<<<.<...]]]]...
>>>>>>>............>>>>..>>>>>>>......<<<<.....<<<
<<...<.........>...>>>>>.....>>>.>.>>......<<<..<<
<<...<<<<<<<<.........>>>>>..>>>..<<<<.....>>>>...
....>>>>......>>>.......<<<<<<<....>>>.>>>>....>>.
.>>>.>>>>>>>.....<<<<<<...<<<<<...<<<<............
......>>......<<<<<<<<>>>>>>>>>>.<<<<<<...<<<<...<
<<<<<<<<<<<<<.<<<..>>>...<<<<...)))))..>>>>.......
.>>>>>>>>>..>>>>>...>>>>.>>>>>>..<<<.<..<<<<<.....
......>>>>>...>>>>.>>>>>...>>>.>>>....<<<.<<<<<...
....>>>>>....<<<<<<<<<<<<....>>.>>>>>>>.>>>.....>>
>....>>>>>>>>.....>>>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ywv Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi.
• Resolution: 3.03 Å
• Binding residue (original residue number in PDB): R10 S11 I13 G14 P16 R18 G21 V22 L23 A24 A25 L28 R29 R30 R31 N32 H37 Q42 F43 G45 M46 K65 R66 K69 D70 R72 P74
• Binding residue (residue number reindexed from 1): R9 S10 I12 G13 P15 R17 G20 V21 L22 A23 A24 L27 R28 R29 R30 N31 H36 Q41 F42 G44 M45 K64 R65 K68 D69 R71 P73

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6ywv, PDBe:6ywv, PDBj:6ywv
• PDBsum: 6ywv
• PubMed: 33056988
• UniProt: Q1K8Y7|RM33_NEUCR Large ribosomal subunit protein uL30m (Gene Name=mrpl33)