Structure of PDB 5ot7 Chain U Binding Site BS01

Receptor Information
>5ot7 Chain U (length=661) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KVEYDLKRLRNIGIAAHIDAGKTTTTERILYYTGRITAAVTTCFWKDHRI
NIIDTPGHVDFTIEVERSMRVLDGAIVVFDSSQGVEPQSETVWRQAEKYK
VPRIAFANKMDKTGADLWLVIRTMQERLGARPVVMQLPIGREDTFSGIID
VLRMKAYTYGNDLGTDIREIPIPEEYLDQAREYHEKLVEVAADFDENIML
KYLEGEEPTEEELVAAIRKGTIDLKITPVFLGSALKNKGVQLLLDAVVDY
LPSPLDIPPIKGTTPEGEVVEIHPDPNGPLAALAFKIMADPYVGRLTFIR
VYSGTLTSGSYVYNTTKGRKERVARLLRMHANHREEVEELKAGDLGAVVG
LKETITGDTLVGEDAPRVILESIEVPEPVIDVAIEPKTKADQEKLSQALA
RLAEEDPTFRVSTHPETGQTIISGMGELHLEIIVDRLKREFKVDANVGKP
QVAYRETITKPVDVEGKFIRQTGGRGQYGHVKIKVEPLPRGSGFEFVNAI
VGGVIPKEYIPAVQKGIEEAMQSGPLIGFPVVDIKVTLYDGSYHEVDSSE
MAFKIAGSMAIKEAVQKGDPVILEPIMRVEVTTPEEYMGDVIGDLNARRG
QILGMEPRGNAQVIRAFVPLAEMFGYATDLRSKTQGRGSFVMFFDHYQEV
PKQVQEKLIKG
Ligand information
>5ot7 Chain 1 (length=1507) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagac
augcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacg
ggugaguaacgcgugggugaccuacccggaagagggggacaacccgggga
aacucgggcuaaucccccauguggacccgccccuugggguguguccaaag
ggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggg
guaauggcccaccaaggcgacgacggguagccggucugagaggauggccg
gccacaggggcacugagacacgggccccacuccuacgggaggcagcaguu
aggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggag
gaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccga
cgaggggacugacgguaccgggguaauagcgccggccaacuccgugccag
cagccgcgguaauacggagggcgcgagcguuacccggauucacugggcgu
aaagggcguguaggcggccuggggcgucccaugugaaagaccacggcuca
accgugggggagcgugggauacgcucaggcuagacggugggagagggugg
uggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccg
auggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcg
uggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaug
cgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgc
gccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacggg
ggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaaga
accuuaccaggccuugacaugcuagggaacccgggugaaagccuggggug
ccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucg
ugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguu
aguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcg
ggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggc
gacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggg
gagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccg
accccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggu
gaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgg
gcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggc
ccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggc
uggauca
....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<
.<<<..<<<..<<.<<<<<...<.......>...>>>>>.>>>>>.....
.<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<<..
..>>>>>>.>...>>>>>....<<<<...<<<....>>>...>>>>...<
<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<...<<<<<<<
.......>>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>
>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>
>.....<<.<<<....<<<<....>>>>..>>>>>.>.>>>>>>..<<<<
......<<<<....>>>>.....>>>>....<<<<<........<<<<..
...>>>>..........>>>>>......<<<<<(((...<<<<<.....<
<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((
.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<....
.>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<
<......<<<<<....<<........>>.......>>>>>..........
...<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<
<<<...<<...<<<<.........>>>>...>>>>>>>>..........<
<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>
>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<
<<<<<<.<<..<<<....<<<<....<.......<<........>>....
.......<.<<<......................................
...........................<<<..<<<<<<.<.....<<<<<
<<<<....>>>..<<<<......>>>>..>>>>>>......<<<.<<<.<
.....<....<.......>..>......>.>>>.....<<<........>
>>........>>.>.....>...>>>...>>>>>>.......>>>..>..
..>.....>>>>.....<<..........<<...<<..<.<.......>.
>.>>.....>>..........>>...............<...........
..>...............>>>.....<.<<<<<..........>>>>>.>
......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<
<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>
>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>
>......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5ot7 The structure of an elongation factor G-ribosome complex captured in the absence of inhibitors.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		Y321 V322 G323 Y340 R351 R354 R499 R504 I529 K536 S571
Binding residue
(residue number reindexed from 1)		Y292 V293 G294 Y311 R322 R325 R470 R475 I500 K507 S542
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0032790 ribosome disassembly
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5ot7, PDBe:5ot7, PDBj:5ot7
PDBsum5ot7
PubMed29408956
UniProtQ5SHN5|EFG_THET8 Elongation factor G (Gene Name=fusA)

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