Structure of PDB 4zkr Chain U Binding Site BS01

Receptor Information
>4zkr Chain U (length=246) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFID
YPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIAL
LKIRSKEGRCAQPSRTIQTIALPSMYNDPQFGTSCEITGFGKEQSTDYLY
PEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGG
PLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTK
Ligand information
Receptor-Ligand Complex Structure
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PDB4zkr The crystal structure of mupain-1-IG in complex with murinised human uPA at pH7.4
Resolution1.36 Å
Binding residue
(original residue number in PDB)		D189 S190 S195 S214 W215 G226
Binding residue
(residue number reindexed from 1)		D192 S193 S198 S217 W218 G229
Enzymatic activity
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4zkr, PDBe:4zkr, PDBj:4zkr
PDBsum4zkr
PubMed
UniProtP00749|UROK_HUMAN Urokinase-type plasminogen activator (Gene Name=PLAU)

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