Structure of PDB 4u7u Chain U Binding Site BS01

Receptor Information

>4u7u Chain U (length=354) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MSNFINIHVLISHSPSCLNRDDMNMQKDAIFGGKRRVRISSQSLKRAMRK
SGYYAQNIGESSLRTIHLAQLRDVLRQKLGERFDQKIIDKTLALLSGKSV
DEAEKISADAVTPWVVGEIAWFCEQVAKAEADNLDDKKLLKVLKEDIAAI
RVNLQQGVDIALSGRMATSGMMTELGKVDGAMSIAHAITTHQVDSDIDWF
TAVDDLGTQEFSSGVFYRYANINLAQLQENLGGASREQALEIATHVVHML
ATEVPGAKQRTYAAFNPADMVMVNFSDMPLSMANAFEKAVKAKDGFLQPS
IQAFNQYWDRVANGYGLNGAAAQFSLSDVDPITAQVKQMPTLEQLKSWVR
NNGE

Ligand information

>4u7u Chain X (length=61) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

auaaaccgggcucccugucgguuguaauugauaauguugagaguuccccg
cgccagcgggg

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Receptor-Ligand Complex Structure

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Structure summary

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PDB	4u7u Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli
Resolution	3.003 Å
Binding residue (original residue number in PDB)	N19 R20 K27 S40 Q42 S43 R46 M166
Binding residue (residue number reindexed from 1)	N19 R20 K27 S40 Q42 S43 R46 M166

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0071667	DNA/RNA hybrid binding

	Biological Process
GO:0051607	defense response to virus
GO:0099048	CRISPR-cas system

	Cellular Component
GO:0032991	protein-containing complex

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Cellular Component

External links

PDB	RCSB:4u7u, PDBe:4u7u, PDBj:4u7u
PDBsum	4u7u
PubMed	25118175
UniProt	Q46899\|CASC_ECOLI CRISPR system Cascade subunit CasC (Gene Name=casC)

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