Structure of PDB 3oy6 Chain U Binding Site BS01

Receptor Information
>3oy6 Chain U (length=247) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFID
YPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIAL
LKIRSKEGRCAQPSRTIQTIALPSMYNDPQFGTSCEITGFGKEQSTDYLY
PEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGG
PLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKE
Ligand information
Receptor-Ligand Complex Structure
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PDB3oy6 The binding mechanism of a peptidic cyclic serine protease inhibitor
Resolution2.31 Å
Binding residue
(original residue number in PDB)		R35 H57 C58 D60A Y60B L97B H99 D189 S190 C191 Q192 S195 S214 W215 R217 G219
Binding residue
(residue number reindexed from 1)		R20 H46 C47 D50 Y51 L92 H94 D192 S193 C194 Q195 S198 S217 W218 R220 G221
Enzymatic activity
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3oy6, PDBe:3oy6, PDBj:3oy6
PDBsum3oy6
PubMed21802428
UniProtP00749|UROK_HUMAN Urokinase-type plasminogen activator (Gene Name=PLAU)

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