Structure of PDB 7nwg Chain T2 Binding Site BS01

Receptor Information
>7nwg Chain T2 (length=144) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADID
LTKRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLAN
GLDNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRRGRT
Ligand information
>7nwg Chain A2 (length=1740) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucagaucaaaaccaacccggucaggcggcuuuggugac
ucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucga
acgucugcccuaucaacuuucgaugguagucgccgugccuaccaugguga
ccacgggugacggggaaucaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacuccc
gacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggc
ccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauugg
agggcaagucuggugccagcagccgcgguaauuccagcuccaauagcgua
uauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggg
cggccguccguccccugccucucggcgccccggggcccgaagcguuuacu
uugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuagg
aauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugagg
ccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggu
gaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaag
aauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucaga
uaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcg
uuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuugggu
uccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaag
ggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaa
ccucacccggcccggacacggacaggauugacagauugauagcucuuucu
cgauuccgugggugguggugcauggccguucuuaguugguggagcgauuu
gucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuac
gcgaccccggucggcguaacuucuuagagggacaaguggcguucagccac
ccgagauugagcaauaacaggucugugaugcccuuagauguccggggcug
cacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcag
gcgcggguaacccguugaaccccauucgugauggggaucggggauugcaa
uuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugc
guugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgau
uggaugguuuagugaggcccucggaucggccccgccggggugcccuggcg
gagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucg
uaacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<<...(((.>>>>><<<.<<<<<<...<.<<..<......<<..
<<<..<<....<.......................>.>>......<<...
.....<<<.<..........<<<...........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<......>>>>>..
.>>>><<..<<<<<.......(((.....<........>......<....
.>..>>>>>......>>...<<<<..<.....>.>>>>....>>>.....
..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>..
....>>>....<<.<<<<....>>>>....>>..>>.<<.<<.<......
...>>>.>>...<<....>>.....>>>.>>.........<<<....<<<
.....>>>..>>>..>...>>.>.....<<<.<<<<..<<<....>>>..
.>>>>..>>>......<<..<...........>..>>.........<<<<
<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>
>.>>>...........<[[.....<.<<...<<<.<<....<<<.<<<<.
<<..>>.>>>>.>>>....<........<<..>.>.....>....<<<<<
<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>
..>>>..........<<.<<<<<<<.........)))...>>>>>>>.>>
......>>....<<<<<<......<<<<...<..<<<<<<<<...<<<..
....>>>......>>>>>>>>..>........<<....>>...>>>>...
..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<....
.>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<
<<<......>>>>>>>>>>.>..>>>...<<..]]>>...>>.....>>>
.>...<<<......<<<......>>>....>>>...)))..<<<<<.<<<
<<<<..<<..<<<<...<<<.<<<<<<......<<........>>.....
.....<<.<<......<<..<<.......<<.<<<........>>>.>>.
....>>..>>...<..<<<..<<.<<<<<.....<<<.<<<<......>>
...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<
<.<.<....>>...>>>>>>>..>>>>..>.....<<<<<.....>>>>>
........>>>.....>>.>>>.....>>>>>.>.......>>.>>...>
>.>>>>.>>>.....<<.<<<................<<<.<<<<....>
>>>.>>>..............>>>.>>.............<<<<......
....>>>>.............>>>>.....<<<<<<<<.......>>>>>
>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<..<...
.<<<<<<<<.<<<..<<.<<<<...<<<<<.<<<<<<<<<..>>>>>>>>
>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>..>>>>...>.>>
...>.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7nwg Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		K25 F28 R38 W82 Q87 K88 H120 H125 L129 R130 V131 R132 G133 H135 K137 T139 R141 R144 T145
Binding residue
(residue number reindexed from 1)		K24 F27 R37 W81 Q86 K87 H119 H124 L128 R129 V130 R131 G132 H134 K136 T138 R140 R143 T144
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022626 cytosolic ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7nwg, PDBe:7nwg, PDBj:7nwg
PDBsum7nwg
PubMed34157102
UniProtG1TPG3|RS18_RABIT Small ribosomal subunit protein uS13 (Gene Name=RPS18)

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