Structure of PDB 6hcm Chain T1 Binding Site BS01

Receptor Information
>6hcm Chain T1 (length=144) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADID
LTKRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLAN
GLDNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRRGRT
Ligand information
>6hcm Chain A1 (length=1732) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucagaucaaaaccaacccggucaggcggcuuuggugac
ucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucga
acgucugcccuaucaacuuucgaugguagucgccgugccuaccaugguga
ccacgggugacggggaaucaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacuccc
gacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggc
ccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauugg
agggcaagucuggugccagcagccgcgguaauuccagcuccaauagcgua
uauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggc
cguccccugccucucggcgccccggggcccgaagcguuuacuuugaaaaa
auuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaaugg
aauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauu
aagagggacggccgggggcauucguauugcgccgcuagaggugaaauucu
uggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuu
cauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucg
uaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauuccc
augacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggg
gaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccac
caggaguggagccugcggcuuaauuugacucaacacgggaaaccucaccc
ggcccggacacggacaggauugacagauugauagcucuuucucgauuccg
ugggugguggugcauggccguucuuaguugguggagcgauuugucugguu
aauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccc
ggucggcguaacuucuuagagggacaaguggcguucagccacccgagauu
gagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcg
cuacacugacuggcucagcgugugccuacccuacgccggcaggcgcgggu
aacccguugaaccccauucgugauggggaucggggauugcaauuauuccc
caugaacgaggaauucccaguaagugcgggucauaagcuugcguugauua
agucccugcccuuuguacacaccgcccgucgcuacuaccgauuggauggu
uuagugaggcccucggaucggccccgccggggugcccuggcggagcgcug
agaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagg
uuuccguaggugaaccugcggaaggaucauua
...<<<<<.{.((((>>>>><<<.<<<<<<.....<<..<......<<<.
<<<...<....<<....<<..........>>...>>.>.......<<...
.....<<<.<....<<....<<<<..........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<......((((.((.<<..<...>.>>....<.....
.>..>>>>>......>>...<<<<..<<<.>>>.>>>>..>.>>>...>>
..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>..
....>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<.......
...>>>.>>...<<....>>.....>>>>>>.........<<<....<<<
.....>>>..>>>..>...>>.......<<<<<<<<<.<<......>>..
>>>>>>.>>>......<<..<...........>..>>.........<<<<
<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>
>.>>>.........<..[[.....<.<<...<<<.<<....<<<.<<<..
>>>.>>>...........<.<<<.>>>>.........<<<<<<.<.....
..<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>...
.......<<.<<<<<<<......)).))))..>>>>>>>.>>......>>
....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>.
.....>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>
>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>.
..>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<......
..>>>>>>>>>.>..>>>...<<..]]>>...>>.....>>>...>.<<<
......<<<......>>>....>>>..)))).}<<<<<.<<<<<<<...<
..<<<<<..<<<.<<<<<<......<<........>>..........<<<
<<......<<<<<........<<.<<<........>>>.>>......>>>
>>...<<.<<<..<<.<<<<<.....<<<.<<<<......>>...<<<..
....>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<.<<<..
>>>..>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........
>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>
>>.....<<.<<<................<<<.<<<<....>>>>.>>>.
.............>>>.>>............<<<<<..........>>>>
>...........>>>>>.....<<<<<<<<.......>>>>>>>>.....
.>....>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<
<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>
>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>........
..<<<<<<<<....>>>>>>>>..........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6hcm ZNF598 Is a Quality Control Sensor of Collided Ribosomes.
Resolution6.8 Å
Binding residue
(original residue number in PDB)		K25 F28 K34 G35 V36 G37 R38 R39 Y40 W82 F83 N85 Q87 L107 H120 R121 R130 V131 R132 G133 Q134 H135 T136 K137 T138 R141 R144
Binding residue
(residue number reindexed from 1)		K24 F27 K33 G34 V35 G36 R37 R38 Y39 W81 F82 N84 Q86 L106 H119 R120 R129 V130 R131 G132 Q133 H134 T135 K136 T137 R140 R143
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022626 cytosolic ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6hcm, PDBe:6hcm, PDBj:6hcm
PDBsum6hcm
PubMed30293783
UniProtG1TPG3|RS18_RABIT Small ribosomal subunit protein uS13 (Gene Name=RPS18)

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