Structure of PDB 8imx Chain T Binding Site BS01

Receptor Information
>8imx Chain T (length=530) Species: 9606,86521 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPRDSLREELVITPLPSGDVAATFQFRTRWDSELQREGVSHYRLFPKALG
QLISKYSLRELHLSFTQGFWRTRYWGPPFLQAPSGAELWVWFQDTVTDVD
KSWKELSNVLSGIFCASLNFIDSTNTVTPTASFKPLGLANDTDHYFLRYA
VLPREVVCTENLTPWKKLLPCSSKAGLSVLLKADRLFHTSYHSQAVHIRP
VCRNARCTSISWELRQTLSVVFDAFITGQGKKDWSLFRMFSRTLTEPCPL
ASESRVYVDITTYNQDNETLEVHPPPTTTYQDVILGTRKTYAIYDLLDTA
MINNSRNLNIQLKWKRPPENEAPPVPFLHAQRYVSGYGLQKGELSTLLYN
THPYRAFPVLLLDTVPWYLRLYVHTLTITSKGKENKPSYIHYQPAQDRLQ
PHLLEMLIQLPANSVTKVSIQFERALLKWTEYTPDPNHGFYVSPSVLSAL
VPSMVAAKPVDWEESPLFNSLFPVSDGSNYFVRLYTEPLLVNLPTPDFSM
PYNVICLTCTVVAVCYGSFYNLLTRTFHIE
Ligand information
>8imx Chain D (length=27) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GTTQLRATATTLILCCLLIILPCFILP
Receptor-Ligand Complex Structure
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PDB8imx Structures of substrates- and products-bound glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis
Resolution2.85 Å
Binding residue
(original residue number in PDB)		P525 Y526 N527 C530 T534
Binding residue
(residue number reindexed from 1)		P501 Y502 N503 C506 T510
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0008218 bioluminescence
GO:0016255 attachment of GPI anchor to protein
Cellular Component
GO:0042765 GPI-anchor transamidase complex

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8imx, PDBe:8imx, PDBj:8imx
PDBsum8imx
PubMed37684232
UniProtQ969N2|PIGT_HUMAN GPI transamidase component PIG-T (Gene Name=PIGT);
Q9U6Y3|GFPL_CLASP GFP-like fluorescent chromoprotein cFP484

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