Structure of PDB 8i0p Chain T Binding Site BS01

Receptor Information
>8i0p Chain T (length=320) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDL
ASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRH
YHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAV
ATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPR
HYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADN
GTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEAD
KTIKVYREDDTATEETHPVS
Ligand information
>8i0p Chain B (length=98) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccg
uggagaggaacaaccccaauuuuuugaggccuugcuuuggcaaggcua
.<<<<<<<<<<<........<<<<<<<<.<.......>.>>>>>>>>...
>>>>>>>>>>>................<<<<<<<<....>>>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8i0p Molecular Basis for the activation of Human spliceosome
Resolution3.4 Å
Binding residue
(original residue number in PDB)		Y277 K279
Binding residue
(residue number reindexed from 1)		Y94 K96
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0034504 protein localization to nucleus
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0000974 Prp19 complex
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005662 DNA replication factor A complex
GO:0005681 spliceosomal complex
GO:0016607 nuclear speck
GO:0031965 nuclear membrane
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8i0p, PDBe:8i0p, PDBj:8i0p
PDBsum8i0p
PubMed39068178
UniProtO43660|PLRG1_HUMAN Pleiotropic regulator 1 (Gene Name=PLRG1)

[Back to BioLiP]