Structure of PDB 8c8y Chain T Binding Site BS01

Receptor Information
>8c8y Chain T (length=93) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIREERLLKVLRAPHVSEKASTAMEKSNTIVLKVAKDATKAEIKAAVQKL
FEVEVEVVNTLVVKGKVKRHGQRIGRRSDWKKAYVTLKEGQNL
Ligand information
>8c8y Chain A (length=2548) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgau
gaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguu
auaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuau
cauuaacugaauccauagguuaaugaggcgaaccgggggaacugaucuaa
guaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcg
aacggggagcagcccagagccugaaucaguguguguguuaguggaagcgu
cuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcaca
ugcugugagcucgaugaguagggcgggacacgugguauccugucugaaua
uggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaa
ccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaa
agaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugu
gacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaag
guuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguua
aguugcaggguauagacccgaaacccggugaucuagccaugggcagguug
aagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaau
uagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagaua
gcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucucc
ggggguagagcacuguuucggccgaugcaaacugcgaauaccggagaaug
uuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaa
acaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaac
gaugugggaaggcgucggccugcgcggaagauguaacggggcuaaaccau
gcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcgu
ucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaag
ugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgcc
ggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgac
cccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuc
cuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccg
ggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauc
cggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagca
acaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaa
ucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuu
gagagaacucgggugaaggaacuaggcaaaauggugccguaacuucggga
gaaggcacgcugauauguaggugaggucccucgcggauggagcugaaauc
agucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugu
gcaaacacgaaaguggacguauacggugugacgccugcccgguguaaacg
gcggccgacgguccuaagguagcgaauggcguaaugauggccaggcuguc
uccacccgagacucagugaaauugaacucgcugugaagaugcaguguacc
cgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacuga
acauugagccuugauguguaggauaggugggaggcuuugaaguguggacg
ccagucugcauggagccgaccuugaaauaccacccuuuaauguuugaugu
ucuaacguugacccguaauccggguugcggacagugucugguggguaguu
ugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguugg
cuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuu
gacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauc
cggugguucugaauggaagggccaucgcucaacggauaaaagguacuccg
gggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuag
uacgagaggaccggaguggacgcaucacugguguucggguugucaugcca
auggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcauc
uaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguc
cugaaggaacguugaagacgacgacguugauaggccggguguguaagcgc
agcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu
<<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<...
...<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>...
...>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<
<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<..>...
...>>>>>.>.........<<....>>..<<<<<<.....<<.....>>.
...>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<
<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>
>>>>>...>>>>........<<<<<<<<.........>>>>>>>>.....
.<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]].........
......<<....>>....]].........<<<<.....>>>>........
.....}....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>
..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<
<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>....
.>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<..
..<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>
>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>.
.>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<
<<.....<<<...<<<.<<<..>>>.>>>..>>.>.....>>>>>>.>>>
...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<..
....>>>...<<<<.<<<...<<<(((.....<<<<<<...........<
<..<<<<<..<<..>>..>>>>>.>>...........))).....>>>>>
>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>><.<
<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.
.>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<
....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.
<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>
>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<
<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>
>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>
>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.
>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<
<<<....<<<<<<<<.<<...............<<<<<....<<..>>..
...>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>
>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<
.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<....>>>
>>.<<<<.>>>>...............>>>>>..>>.>>>>>>>.....>
>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<
<<<<<<.(((.[[......<<<<.[[<<<<...<<<<.<<<.<<<<<.<<
<<<<<<.<..<<<............<<<<<...<<.......<<<..<..
....>..>>>....>>.............>>>>>...>>>..>>.>>>>>
>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>..
.<<<.......>>><<<<<<...........>>>>>>..<<...<<<<<<
<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>.
..<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......
<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>
>>...]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...
............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).
>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<.........
..>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>
<....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<
<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.
Receptor-Ligand Complex Structure
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PDB8c8y Cryo-EM captures early ribosome assembly in action.
Resolution3.03 Å
Binding residue
(original residue number in PDB)		M1 R3 H15 S17 E18 K19 K40 N59 V62 K64 K66 R73 G75 R77 S78 K81 K82 Y84
Binding residue
(residue number reindexed from 1)		M1 R3 H15 S17 E18 K19 K40 N59 V62 K64 K66 R73 G75 R77 S78 K81 K82 Y84
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8c8y, PDBe:8c8y, PDBj:8c8y
PDBsum8c8y
PubMed36797249
UniProtP0ADZ0|RL23_ECOLI Large ribosomal subunit protein uL23 (Gene Name=rplW)

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