Structure of PDB 7pwg Chain T Binding Site BS01

Receptor Information
>7pwg Chain T (length=153) Species: 184922 (Giardia lamblia ATCC 50803) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
THSQGYRCKTRYCFARKFRRHGMANLTTYNRVYKLGQYVNIKVNGAYHKG
MPHRYYNGRTGTIFNIGPRALGVQIQKRVRGRIMLKRINVRLEHVHPSDC
RKNHLERVAANDAARRLAGQPVPCLKRQNALPRAAHVVSIASAIDITPLK
YDG
Ligand information
>7pwg Chain 1 (length=2450) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cggcccgaggcggcgggggcgacgggcggaacuuaagcauaucaguacgc
cccggaggagaaaccaaccgggauuccccguagcggcgagcgacgcggga
ggagcccgccccgaaggcgcgcugugggcgccgcgagggggcccgagggc
cccgcccgagagggugcaagccccguacggcgggcgaguagcgcugcuug
agcgugcagcgcgaagggaggcgcggcccuuccaaggcuaaauacgcccc
gggaccgauagcggaccaaguagcgcgagcgaacggugaaaaggacgccc
ggccgcucaaaagaccugaacccggccggcgccggcccgccggccccguc
ucgaaacacggaccgaggagccacgcgccgcggcgagcccgagggccccg
cggcggagcgagcgcgagacgccccgggcccgccgcgccccugcgggcgu
gcgcgggccgagccgcggcgcgugggcccgaaaggcggugaucuaugccc
ggcgagggcgaggccgggcgaaagccugguggaggcccgccgcggugcug
acgcgcagaucgcucgucggagccgggcaugggggcgaaagacucaucga
accgccugguagcugguugccuccgaaaugucucccaggacagccgccgc
ccgcaguugcggcccguagagcgcuggccggcggccgccccccaaacucc
gaagggccgcgccgccccgcccuggccugggcggggcgggcgaaugcggg
cggcgcgugggccccuccugguaagcaggacgggcgaggcgggacgaucc
ggacgccgggccagggugcgccgccggggccggaacggcgucggccgcgg
ccggcccggaaaauggagcgcgccggagccccggacccgcgcccggccgc
cgcgcgcggcggguaggaggccgcagaggccccgggggcgaaggcggcgc
gcaggccccgccggaccggccucuggugcagaucucggcagcaguagcgc
uacuccgcgccccggaggacugagggggagacggguuccgcggcgccugc
aucuggccgcgggugacucgggccuaagcggcgggugaagaccgggaagg
ggcgugcccgcccgucgaacggggagccggcggagacuccggcaggcgcg
ggcggagacgcgccccccggcgacgcgcacggggaccgcggcgggcggcg
ccccggcccgcgaacgccccgcagcccccggacgccuugcgcggagaggg
gggcccgggggcggaccgcgcguccccggccgccccugaaaagccggggg
gcccgcgcgccguaccgaccgcacaggacuccggggucagcagccucuag
cgcgggagcgaacgcggcucagggaagucggcaagccggcuccguaaccu
cgggaaaaggaguggcucugacggggucagaacuggaacggacgcgggga
ucccgacuguuuacuagaaacacagcgucgcgagggccgcacccggcgcu
ggcgcgacgugauuucugcccagugccagaccgucaccgugaagcgaucc
gccgaagcccugguaaacggcgggaguaaugacucucuuaagguagccaa
augccucgucgggcaauuuccgacggcaugaauggaccaacgaggauccc
acugucccgagccgcgccuccgcgagccuccagccucgggaacgggcgag
ggccggccagcggggcaagaagacccuuuugagcuugacuccagcccggg
ccuguggggcggggccgccccgcucacccggucgcgcggggacccgcccg
ggcggggaguucggcuggggcggcgcgccugcuacaccggaccgcaggcg
ucccacggcgggcucagcgaggacccucccgcggagcagaagggcacaag
cccgcccgacccgcgccccccgugccggcgcgggccgcgaaagcggggcc
uaccgauccuucgccgccccggccgcgggcgcggagguggcagaaaaguu
accacagggauaacuggcuuguggccgccgagcgcccgcagcgacgcggc
uuuuugauccuucgaugucggcucuuccuaccguccgcgcgcaccggcgc
ggaagcgucggauuguucacccguucaagggaucgugagcuggguuuaga
ccgucgugagacgguuaguuuuacccuacuggccccggggccagagcacg
gcgggccaguacggaggaacgcccgccgcgggcgcccagccccgcgguug
cccgccggggcaggaccgcgcgcccgggcccgggggccuggcgcugccgc
cucuaaagcgccaccccccccuccggccccgccgcccgcgccccagcccc
gugcccccugcccgaggcggcccccgcccgggaggaccacccggcgcggc
gccccuguacggcgagggcgcguucgcccggggggcgcgccgcgggcgcg
......................<<<<<<.....<<....>>......>>>
>>.>.........<<....>>..<<<<<....<<.....>>.....>>>>
>..[[[...<<<<...........>>>><<<<.....<<<<<......>>
>>>((......<<<.....))>>>....>>>>........<<<<<<<...
.....>>>>>>>...(((((..<<<<<<)))))..]]]............
......................<<....>>................<<<.
>>>...........................<<<<<<..>>>>>>.<<<<.
.......>>>>.<<<<<....<<<<<<<<<<<<<..<<<...<<<.>>>.
.>>>...<<....>>............<<<<<<<<<<<<<....>>>>>>
>.>>>>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<
<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<
<........>>>>.>>>....>>>>>>>>>...<<.......>>......
>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<
<<<<<.<<<<<<<<<...<<<...<<<..<<<<..>>>>..>>>..>>.>
...>>>>>>>.<<<<<<<<<<<......>>>>>>>>>>>...>>>>>>>>
>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>
>...<<<<<<<..<<<<(((...<<<<<<<.....<<<.<<<<<<<..>>
>>>>>>>>..........)))......>>>>>>>>>>>..>>>>>>><<<
<<....>>>>>....>>>>>><<<<<<<<<<...<<......<<<<<.<<
....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>.<<.....<<..
..<<<<<.....>>>>>..<<.....<<<<..<<...<<<<<<...<...
....>.>>>>>>....((<<<.<<...<<<...<<<....>>>......<
<<<..>>>>...>>.>....>>...<<<<<........>>>>>))<<<<<
<<<<....>>><<<<<<<<<<...<<<..<<<<<<<<<<<<<<<<<....
.....>>>>>....<<<<<<...<<<<<<....<<.....>>......>>
>>>>...>>>>>>..>>>>>.>>>>>>>..>>>.........>>>>>>>>
>>>>>>>>.>>>..>>..<<.....>>.>>>>.<<<<.....>>>>..>>
....<<<<....<<<<<<<<.<<.........<.....<<<<<....<<.
.>>.....>>>>><<.<<<<<<...>>>>>>.>>............<<<<
<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>...
...>>>>>>>...<<..<<<..<<<<<<<...<<....<<<.<....>.>
>>....>>.>>>>>..>>>>><<<<<<....>>>>>>........<....
.......<<<<<<.....>>>>>>....>.....>>....>>.>>>>>>>
..>..>>.>>>>>>>>.>>>>>>....>>....<<<<<........>>>>
>...((((((..{{{.........{{{..{{[[[[..<<<<<.<<<<<<<
<..<<<<<<<<<..>>>>>>>>>...<<<<......>>>>.....>>>>>
>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>.
.<<...<<<<<<<...<.<<<<..>>>>.>.....<<...(((>>....>
>>>>>>...<<<<<<<<.........>>>>>>>>.<<<....>>>.>>))
).......(((((.(((((.>>>>>>))))))))))..........]]]]
..}}.}}}.......<<.<.<.<<<<<<...<<.......>>...>>>>>
>...>>.>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>
>>..>>>.<<<.........>>>....>>>>>..>...>>>.>>....<<
<<<<<....>>>>>>>........}}}.))))))..<<<<<<.<<<..<<
<<<<<<..............>>>>>>>><<<<<...<.<....<<<<<<<
<<<....>>>>>..>>>>>....>.>.>>>>>.<<<...<<<<<<.....
......>>>>>>...>>>..>>>.>>>>>>...<.<<<............
.................>>>.>...<<.<<<<.......>>>>..<<<<<
<<<<<<....<<<<<<.<..>.>>>>>>...>>>>.>>>>>>>....>>.
Receptor-Ligand Complex Structure
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PDB7pwg Cryo-EM structure of the ancient eukaryotic ribosome from the human parasite Giardia lamblia.
Resolution2.75 Å
Binding residue
(original residue number in PDB)
T2 H3 S4 Q5 G6 Y7 R8 C9 R12 R17 F19 H22 K35 Y39 K43 A47 H49 H54 R55 G59 R60 T61 R70 A71 Q77 K78 V80 R83 M85 K87 R88 R92 C101 R102 H105 R108 V109 N112 R116 L129 K130 R131 N133
Binding residue
(residue number reindexed from 1)
T1 H2 S3 Q4 G5 Y6 R7 C8 R11 R16 F18 H21 K34 Y38 K42 A46 H48 H53 R54 G58 R59 T60 R69 A70 Q76 K77 V79 R82 M84 K86 R87 R91 C100 R101 H104 R107 V108 N111 R115 L125 K126 R127 N129
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7pwg, PDBe:7pwg, PDBj:7pwg
PDBsum7pwg
PubMed35100413
UniProtA8B2Q4

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