Structure of PDB 7oic Chain T Binding Site BS01

Receptor Information
>7oic Chain T (length=166) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ISRKWEKKNKIVYPPQLPGEPRRPAEIYHCRRQIKYSKDKMWYLAKLIRG
MSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAVRDHNVEFRSNLYIAEST
SGRGQCLKRIRYHGRGRFGIMEKVYCHYFVKLVEGPPPPPEPPKTAVAHA
KEYIQQLRSRTIVHTL
Ligand information
>7oic Chain A (length=1383) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccccaccuuacuaccaaaccuuagccaaacc
auuuaccaaaauaaaguauaggcgauagaaauugacuggcgcaauagaua
uaguaccgcaagggaaagaugaaaaaaccaagcauaauauagcaaggacu
aaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaagg
agagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcu
aaaagagcacacccgucuauguagcaaaauagugggaagauuuauaggua
gaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaa
ucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauu
uaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccu
uguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagcca
ccaauuaagaaagcguucaagcucaacaccaaaaaucccaaacauauaac
ugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacua
auguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcguc
agauacugacaauuaacagcccaauaucuacaaucaaccaacaagucauu
auuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaa
aaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaac
aucaccucuagcaucaccaguauuagaggcaccgccuuggcuccacgagg
guucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaaga
ggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuau
uaaugcaaacaguaaccugcauuaaaaauuucgguuggggcgaccucgga
gcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagc
gaaccucaauugauccaauaacuugaccaacggaacaaguuacccuaggg
auaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacga
ccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguu
cguuuguucaacgauuaaaguccuacgugaucugaguucagaccggagua
auccaggucgguuucuaucuacuuuauuccucccuguacgaaaggacaag
agaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucauc
ucaacuuagauacccacacccaagaacaggguu
<<<.......<<<<...............................<....
..>...............<<.....>>..........>>.>>........
.....<<....>>.................>>>...........<<<...
....>>>...<.<........>.>.<<<<<<.........<<<.<<..<<
....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<
.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>.
..<<.......>>......>.>>>>......>.>>..<<<<<<....<<<
<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>
>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.<.<<<......>>>
.>..<<<.<<<...<..............<....<<<.........>>>.
...>.......<<<......>>>...........................
>...>>>>>>........>>>>>>...<<<<<......>>>>>.......
..>>>>>><......<<..<<<....>>><<<<..<<<<........<<<
<<...>>>>>......<<<...<<<<.......................>
>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<..
.<<<<<<<<.<<.........<......<<<<<<..<<<.........>>
>...<<<<<<.............>>>>>>....<<<..>>>....>>.>>
>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<......
..>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<
<<<<<<<..........>>>>>>>>>>>>>..<<<<.....>>>><<<<<
<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>
....>>.........<<<....>>>............>>>>..>>>>>>.
......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.
>.......<.<<<..<<<<<..<<.<<<<<<......>>>>>>...>>.<
<<<<.....>>>>>.....>>>>>......>>>..>....<<<<<<<...
.>>>.>>>>....>>..>>>.>>..<<<.<<<.................>
>>.>>><<<<<...<<<....>>>.>>>>>......<<<...........
.....>>>.........<<<<.......>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7oic A distinct assembly pathway of the human 39S late pre-mitoribosome.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		I47 S48 K50 W51 K54 R78 K81 Y82 S83 K86 W88 R95 D110 K111 K112 T146 R149 G150 Q151 R157 Y158 H159 G160 R161 G162 R163 F164 I166 M167 E168 K169 H173 F175 S205 R206 T207 H210
Binding residue
(residue number reindexed from 1)		I1 S2 K4 W5 K8 R32 K35 Y36 S37 K40 W42 R49 D64 K65 K66 T100 R103 G104 Q105 R111 Y112 H113 G114 R115 G116 R117 F118 I120 M121 E122 K123 H127 F129 S159 R160 T161 H164
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7oic, PDBe:7oic, PDBj:7oic
PDBsum7oic
PubMed34315873
UniProtQ9NWU5|RM22_HUMAN Large ribosomal subunit protein uL22m (Gene Name=MRPL22)

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