Structure of PDB 7o9m Chain T Binding Site BS01

Receptor Information
>7o9m Chain T (length=166) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ISRKWEKKNKIVYPPQLPGEPRRPAEIYHCRRQIKYSKDKMWYLAKLIRG
MSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAVRDHNVEFRSNLYIAEST
SGRGQCLKRIRYHGRGRFGIMEKVYCHYFVKLVEGPPPPPEPPKTAVAHA
KEYIQQLRSRTIVHTL
Ligand information
>7o9m Chain A (length=1454) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccaaaccuuagccaa
accauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgcaa
uagauauaguaccgcaagggaaagaugaaaaaaccaagcauaauauagca
aggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuu
gcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaaga
acagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuua
uagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaag
auagaaucuuaguucaacuuuaaauuugcccacagaacccucuaaauccc
cuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuag
gaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccua
aaagcagccaccaauuaagaaagcguucaagcucaacacccacuaaaaaa
ucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucac
ccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccucc
gcauaagccugcgucagauacacugaacugacaauuaacagcccaauauc
uacaaucaaccaacaagucauuauuacccucacugucaacccaacacagg
caugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuu
accccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagag
gcaccgccugcccagugaucacuuguuccuuaaauagggaccuguaugaa
uggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugac
cugcccgugaagaggcgggcauaacacagcaagacgagaagacccuaugg
agcuuuaauuuauuaaugcaaacaccugcauuaaaaauuucgguuggggc
gaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucacc
agucaaagcgaacacucaauugauccaauaacuugaccaacggaacaagu
uacccuagggauaacagcgcaauccuauucuagaguccauaucaacaaua
ggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcu
auuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguuca
gaccggaguaauccaggucgguuucuaucuacuuucaaauuccucccugu
acgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccgu
aaaugauaucaucucaacuuaguauuauacccacacccacccaagaacag
gguu
<<<.......<<<<..................................<.
.....>...............<<.....>>.............>>.>>..
...........<<....>>.................>>>...........
<<<.......>>>...<.<<......>>.>.<<<<<<.........<<<.
<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<
<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.
>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<.
...<<<<....>>>>.<<.<<<<<<<<<<.....<<..........>>..
...>>>>>>>>>>..>>..<<<<<<<<<<....(.>>>>>>>>>>...<<
<......>>>....<<<.<<<...<..............<....<<<...
......>>>....>.......<<<......>>>.................
...............>...>>>>>>........>>>>>>...<<<<<...
...>>>>>.........>>>>>>.......<<..<<<....>>><<<<..
<<<<........<<<<<..........>>>>>......<<<...<<<<..
.....................>>>>.......>>>.....<<......>>
.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......
<<<<<<..<<<.........>>>...<<<<<<.............>>>>>
>....<<<.....<<<<..>>>>.<<<<<<.....>>>>>>.........
.>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.........
..<<<<<........>>>>>.......<<..<<<.<<<....<<<<<.<<
<<<<..<<<<<.<<<<<<<<......>>>>>>>>>>>>>..<<<<.[.[.
>>>><<<<<.............>>>>>..<<.....<<<..<<<<.....
>>>>..>>>.....>>.........<<<....>>>............>>>
>..>>>>>>>..........<<<<<<<<<...<<.......>>...>>>>
>>>>>)....].].....<<<<<..<<<<<..<<.<<<<<<......>>>
>>>...>>.<<<<<.....>>>>>.....>>>>>......>>>>>.....
<<<<<<<....>>>.>>>>...>>>..>>>.>>.....<<<.<<<.....
............>>>.>>><<<<<...<<<....>>>.>>>>>......<
<<................>>>.................<<<<.......>
>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7o9m Structural basis for late maturation steps of the human mitoribosomal large subunit.
Resolution2.6 Å
Binding residue
(original residue number in PDB)
I47 S48 R49 K50 W51 R78 K81 Y82 S83 K86 W88 R95 D110 K111 K112 R149 Q151 K154 R157 Y158 H159 G160 R161 G162 R163 F164 G165 I166 M167 K169 V170 H173 F175 S205 R206 T207 H210
Binding residue
(residue number reindexed from 1)
I1 S2 R3 K4 W5 R32 K35 Y36 S37 K40 W42 R49 D64 K65 K66 R103 Q105 K108 R111 Y112 H113 G114 R115 G116 R117 F118 G119 I120 M121 K123 V124 H127 F129 S159 R160 T161 H164
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005739 mitochondrion
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7o9m, PDBe:7o9m, PDBj:7o9m
PDBsum7o9m
PubMed34135318
UniProtE7ESL0

[Back to BioLiP]