Structure of PDB 7kd6 Chain T Binding Site BS01

Receptor Information

>7kd6 Chain T (length=47) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

FVNQHLCGSHLVEALYLVCGERGFFRRGIVEQCCHSICSLEQLENYC

Ligand information

>7kd6 Chain X (length=14) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

TFEDYLHNVVFVPR

Receptor-Ligand Complex Structure

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PDB	7kd6 Single-chain insulin analogs threaded by the insulin receptor alpha CT domain.
Resolution	2.6 Å
Binding residue (original residue number in PDB)	G8 V12 F24 F25 R36 G37 I38 V39 E40 E53 N54 Y55 C56
Binding residue (residue number reindexed from 1)	G8 V12 F24 F25 R27 G28 I29 V30 E31 E44 N45 Y46 C47

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005179	hormone activity

	Cellular Component
GO:0005576	extracellular region

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Molecular Function

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Cellular Component

External links

PDB	RCSB:7kd6, PDBe:7kd6, PDBj:7kd6
PDBsum	7kd6
PubMed	36181268
UniProt	P01308\|INS_HUMAN Insulin (Gene Name=INS)

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