Structure of PDB 6zmw Chain T Binding Site BS01

Receptor Information
>6zmw Chain T (length=125) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTPD
VIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKTS
RKQRKERKNRMKKVRGTAKANVGAG
Ligand information
>6zmw Chain A (length=1719) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucugaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgcuccuacuuggauaacugug
guaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggg
gggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucg
cacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacu
uucgaugguagucgccgugccuaccauggugaccacgggugacggggaau
caggguucgauuccggagagggagccugagaaacggcuaccacauccaag
gaaggcagcaggcgcgcaaauuacccacucccgacccggggagguaguga
cgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagu
ccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugcca
gcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcagu
uaaaaagcucguaguuggaucuugggagcggccccgccccucucggcggc
ccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagcc
gccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuu
guugguuuucggaacugaggccaugauuaagagggacggccgggggcauu
cguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggacca
gagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucg
gagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugc
cgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccg
ggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaa
cuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuua
auuugacucaacacgggaaaccucacccggcccggacacggacaggauug
acagauugauagcucuuucucgauuccgugggugguggugcauggccguu
cuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacu
cuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaac
uucuuagagggacaaguggcguucagccacccgagauugagcaauaacag
gucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacug
gcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaac
cccauucgugauggggaucggggauugcaauuauuccccaugaacgagga
auucccaguaagugcgggucauaagcuugcguugauuaagucccugcccu
uuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggccc
ucggaucggccccgccgggggcccuggcggagcgcugagaagacggucga
acuugacuaucuagaggaaguaaaagucguaacaagguuuccguagguga
accugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<.............<<.....<<.<<
<.....>>>.>>......>>.........<<<<...<<<<........>>
>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<
<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<
....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<
....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....
>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>.....
.>>.>.....<.<<...<<..<<....>>..>>.....>>..>.....<<
..<...........>..>>.........<<<<<((....<.<<<<.....
<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<(
(.....<.<<...<<<.<<....<<<..........>>><<.........
....>>...<<<<<<.<.......<<...<.......>.<<<<.......
>>>>...>>......>.>>>..>>>........<.<<.<<<.<.<.....
..........>>..>>>.>>.>....>>....<<<<<<..<...<<<<..
<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.....
..<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<
<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<
<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<
<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....
>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<...
...<<........>>..........<<<<<......<<<<<<.......<
<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<
....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<
<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>
>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>
>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<
<........<.......<<<.<<<<....>>>>.>>>....>........
.>>>.>>..........<.<<<<<..........>>>>>>..........
>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>
>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.
<<...<<<<<.......................>>>>>...>>.>>>>..
>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<...
.>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6zmw Structure of a human 48Stranslational initiation complex.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		R8 T9 R10 K11 F12 T14 K21 K32 A33 T34 V35 P36 K37 Y48 F60 R61 H63 F64 G65 G66 H89 R93 K99 R104 K105 R107 K108 E109 K111 N112 K115 K116 R118 T120
Binding residue
(residue number reindexed from 1)		R5 T6 R7 K8 F9 T11 K18 K29 A30 T31 V32 P33 K34 Y45 F57 R58 H60 F61 G62 G63 H86 R90 K96 R101 K102 R104 K105 E106 K108 N109 K112 K113 R115 T117
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0031369 translation initiation factor binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0034101 erythrocyte homeostasis
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0044391 ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6zmw, PDBe:6zmw, PDBj:6zmw
PDBsum6zmw
PubMed32883864
UniProtP62847|RS24_HUMAN Small ribosomal subunit protein eS24 (Gene Name=RPS24)

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