Structure of PDB 6id0 Chain T Binding Site BS01

Receptor Information
>6id0 Chain T (length=317) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDL
ASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRH
YHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAV
ATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPR
HYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADN
GTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEAD
KTIKVYREDDTATEETH
Ligand information
>6id0 Chain B (length=98) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuucc
guggagaggaacaacucugagucuuaacccaauuuuuugaggccuugc
...<<<<<<<<<<........<<<<<<<<.<.......>.>>>>>>>>..
.>>>>>>>>>>.....................................
Receptor-Ligand Complex Structure
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PDB6id0 Structures of the human spliceosomes before and after release of the ligated exon.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		Y277 K279
Binding residue
(residue number reindexed from 1)		Y94 K96
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0034504 protein localization to nucleus
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0000974 Prp19 complex
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005662 DNA replication factor A complex
GO:0005681 spliceosomal complex
GO:0016607 nuclear speck
GO:0031965 nuclear membrane
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6id0, PDBe:6id0, PDBj:6id0
PDBsum6id0
PubMed30728453
UniProtO43660|PLRG1_HUMAN Pleiotropic regulator 1 (Gene Name=PLRG1)

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