Structure of PDB 3pio Chain T Binding Site BS01

Receptor Information
>3pio Chain T (length=74) Species: 1299 (Deinococcus radiodurans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NGRDSNPKYLGVKKFGGEVVKAGNILVRQRGTKFKAGQGVGMGRDHTLFA
LSDGKVVFINKGKGARFISIEAAQ
Ligand information
>3pio Chain X (length=2657) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaug
aaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuug
acucggggauguccgaauggggaaacccaccucguaagagguauccgcaa
ggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaa
gagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaauc
aagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguagg
cgaacgagaggucguuguucgugaaacgaugacugaauccgcgcggacca
ccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugag
ggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccg
uggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauu
gaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaa
cggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucggg
cuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccggg
gggcggaggaccgaaccggugccugcugaaacagucucggaugaguugug
uuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaa
auguauugagguacagccucggauguugaccauguccuguagagcacuca
caaggcuaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggag
ugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagacc
aucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucg
cauagacagccaggagguuggcuuagaagcagccacccuucaaagagugc
guaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcuca
agugaucuaccgaagcuauggauucaacucggaguugucugguaggggag
cguucaguccgcggagaagccauaccggaaggagugguggagccgacuga
agugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucg
ccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucg
ggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagau
uccugcaccgaucauguggagugauggagggacgcauuacgcuauccaau
gccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucaga
aaaucuaccggucugccucagacguaucgggagcuuccucggaagcgaag
uuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauu
gcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcg
cgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucg
gaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggc
gacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguau
agggugugacgccugcccggugccggaaggucaaguggagcggugcaagc
ugcgaaaugaagccccggugaacggcuaagguagcgaaauuccuugucgg
guaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaac
gagggacucggugaaauugaauuggcuguaaagaugcggccuacccguag
caggacgaaaagaccccguggagcuuuacuauagucuggcauugggauuc
ggguuacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuug
gcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcc
caaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguag
aagguggcuugacugcgagacugacacgucgagcagggaggaaacucggg
cuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaa
aguuaccccggggauaacaggcugaucucccccgagaguccauaucggcg
gggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaa
ggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcugggu
ucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggaga
auugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcu
ggucucccugcugucguaccaacggcacaugcaggguagcuauguccgga
acggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugagu
ucucccacugagguaagacucccggaagaccaccggguuaagaggccagg
cgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggu
cuugacc
.<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<....
..<<<<<<.((..((.>>>.....<<<<<<...<<.))..))..>>....
..>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....
>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........
<<....>>...<<<<......<<.....>>.....>>>>...<<<...<<
..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>
>....>>..<<<<<<<<.........>>>>>>>>......<<<<<..(((
(>>>>>..>>>......>>.>>>>>>.>>..............<<....>
>....>>.........<<<<....>>>>..................>>>>
>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.....
.......>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>
>...>>>...<<....>>...<........>.........>>>>>>>>>>
>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<.>>
>>>......>>>...<<<..<.<<........>>.>.>>>....>>>>>>
>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<...
.<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<
.<<<<.....>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>
>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<
<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<
........<<<<<.<<...<<<<.......>>>>...>>.........<<
......>>...>>>>>....>>>>>>>>>.>>..........))).....
.>>>>>>.>>>...>>>>>>><..<<<<.....>>>>..>....>>>>>>
<.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>
>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<
<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<
<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<.......
.>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.
<<<<.<<...[[....>>>>>><<<<<<<.<<..<<<.<<<<<<...<<.
....>>.>>>>>>..>>>..>>>>>>>>>...<<<<<....>>>>>....
>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>
>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>
..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>
>.....>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<
<..<<...........>>..<<<<<<<.....<<<.....>>>.......
>>>>>>>.<<<<<..<<..<<<<<<<..<<<...<<...<<<<<....>>
>>>...>>...>>>>>>>>..>>>>........<...........<<<<<
.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>
>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<
<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<
<<<<.>>>>>>>>>>>...<<<<<<........>>>>>>....>>>>>.>
>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<
<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>..
..>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>
))).......<<<<<<<.<<..))))..>>>>>>>>>.............
>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>
>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......
>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>.
...<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<
<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<....
<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>..>>>>>..
..<<....<<<<<...........>>>>>....>>..>>>>.......>>
>>>>>..<<.>>....<<<<<<<<<.......>>>>>....<<<<<<<<.
<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>
>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3pio Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit.
Resolution3.2473 Å
Binding residue
(original residue number in PDB)		N12 R14 D15 N17 P18 K19 Y20 V23 K24 F26 G27 E29 A33 G34 N35 I36 R39 R41 G42 T43 F45 R55 D56 F60 F69 R77
Binding residue
(residue number reindexed from 1)		N1 R3 D4 N6 P7 K8 Y9 V12 K13 F15 G16 E18 A22 G23 N24 I25 R28 R30 G31 T32 F34 R44 D45 F49 F58 R66
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3pio, PDBe:3pio, PDBj:3pio
PDBsum3pio
PubMed21282615
UniProtQ9RY65|RL27_DEIRA Large ribosomal subunit protein bL27 (Gene Name=rpmA)

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