Structure of PDB 3jcs Chain T Binding Site BS01

Receptor Information
>3jcs Chain T (length=154) Species: 5661 (Leishmania donovani) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
THYSRKPQVSSKSAKAKVSDLRCHYKNTFETANVINGMPLRKAQQLYRQV
LAKTRCIPFKRYNGKIGRTAQAKEWGQTKGRWPRKSVVAMMSLLKNAEAN
AIEKGLDPNQMVIKHVQVDQAARMRRRTYRAHGRITPYMCSPCHVQLFMS
EKKE
Ligand information
>3jcs Chain 1 (length=1554) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagag
ggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggca
caaauaucauuucgugguuggugcaggaguggcgaaauucaagcgcaaag
caaacccguugcugaauacaacccuucaugugaguauugagccaaagaag
guguuagcccauugagccauaaaccugagcgccucaugaacuguauuaag
cgaguagcacuguuugggaaugcagugucaaguuggcagguauuugucug
ccaaaguuaaauacagaguaggaagaccgauagcgaacaaguagcgugag
cgaaaguuugaaaagcacuuuggaaagagagugaaauagaaccugaaguc
gugacaaagacaauggaaguaccuccauuucaacggccagaaccagcccu
acugcauuauccugucggccggcgggcaacgaagugcaagaauuuugggu
cuuggugaaugcuccauggcgauggaaauggggugcccccacccgucuug
aaacacggaccaaggagucaaacagacgcgcaagggaggagauauccagu
acuucucucguacugaaagggagaugcaaugcaucuguggugugcacacg
ucaaauccguuugauuugcccaacaccgaccggcccuccguggguugcgu
uggagugugccuguuuggacccgaaagguggugaacuaugccugaacaag
gugaagcccgggaacccagguggaggccuguagcgaugcugacgugcaaa
ucgcucguaugauuuggguaucggagcgaaagacucaucgaaccaccuag
uagcugguucacaucgaaguuucccucaggauagcuggugcuaguagaag
uauugugcgguaaagcaugauuagagguugguguuaauaucgaccuauuc
ucacuuuaaaugugcaaacaaaccugccuuagccugcaaggccggaaaga
aauuagaggcaccaagugggccuucuucgguaagcggagcaggcgaugcg
gaaugaaccgcuuagggauauguggcgucaaaacuuaugggcucauucga
uacgugaaaaggguguugguggauaacaaauccaccggccccgaaaaugg
augacgcuuaagcccaauuagugauugcccauuauuccuuugguaagggc
ggaaacuuggagaaaguguagcccuuccgauguagauguggccuggaggu
uaggacgaagcuuauggcgugagccuaagauggaccggccucuagugcag
aucuugguuggcguagcaaagaucuaacggagacguuggauacuggagcg
gggaaggauuucgugccaacggcacucguacacgaguuguucggaaacug
agcacaacguuauaucguuuuguuaggaaagugaaggugugggccauaac
ugaaaaggggcaacagagaaccuggguuauauuccaaaaagaaauugcau
gugg
......................<<<<<......<<....>>.......>>
>>.>...<.....<<....>>..<<<<<<......<<.....>>....>>
>>>>...<<<...<<<<...<<<<<<<......>>>>>.>>.....>>>>
....<..<<.<<<<.<...<<<<..<<.<<<<<.......<.........
.<......<..........>.....>..........>............<
<.......>>.....>>>>>...>>....>>>>.>.>>>>.>>.>.....
......<<<<<<<........>>>>>>>......<<<<<........>>>
>>..>>>....>...............................<<....>
>................<<<<....>>>>.....................
.............<<<..<<<<<<.<<<<<.......<....<.<<....
..........<<<..........>>>.................>>.>...
.....<....>.......>......>>>>>>>>>>>..>>>.<<<<....
....>>>><<<<<<....<<<<<<<.<<<<<..<<<.<<<<.<<<...>>
>>>.>>>>>...<<....>>.....<.....>.....<<<.......<..
..........>........>>>..<<<<<<<.<.......>.>>>>>.>>
....>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<
<....<<<.<<<..>>>.>>>.....>>>...<<<..<<.<<........
>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...
...>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<.
<.<<<<<<<...<<<..<<<....<<<<<<<<<<..>>>>>>>>>>....
>>>>>>....>>>>>>>.....<<.<<<...<<..>>..>>>.>>.....
.>>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<
<..[...>>>>..<<<<<<<...<<<(((........<<<<<......<.
...]......<<...<<<<<<<<<.....>>>>>>>>>..>>........
..))).>....>>>>>..........>>>...>>>>>>><<<<.<<<<<.
.....................>>>>>>>>>....>>>>>....<<<<<<<
<........<<<<..<<<....>>>.>>>.>.....>>>>>>>>......
..>>>>>>..............<<<<<<<....>>>>>>>..........
..........<<<<<....<<.....>>..>>>>>....<<.........
.<<.<<<<<......>>>>...............<<<<.......>>..>
>......>.>>..........<<<..........>....>>.>>......
....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3jcs 2.8- angstrom Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		T2 H3 R6 K16 K18 R23 H25 Y26 K27 F30 N37 R62 Y63 G65 K66 R82 N97 A100 N101 Q118 V119 R127 T129 R131 A132 H133
Binding residue
(residue number reindexed from 1)		T1 H2 R5 K15 K17 R22 H24 Y25 K26 F29 N36 R61 Y62 G64 K65 R81 N96 A99 N100 Q117 V118 R126 T128 R130 A131 H132
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3jcs, PDBe:3jcs, PDBj:3jcs
PDBsum3jcs
PubMed27373148
UniProtA0A3S7WY02

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