Structure of PDB 1htq Chain T Binding Site BS01

Receptor Information
>1htq Chain T (length=477) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TEKTPDDVFKLAKDEKVEYVDVRFCDLPGIMQHFTIPASAFDKSVFDDGL
AFDGSSIRGFQSIHESDMLLLPDPETARIDPFRAAKTLNINFFVHDPFTL
EPYSRDPRNIARKAENYLISTGIADTAYFGAEAEFYIFDSVSFDSRANGS
FYEVDAISGWWNTGAATEADGSPNRGYKVRHKGGYFPVAPNDQYVDLRDK
MLTNLINSGFILEKGHHEVGSGGQAEINYQFNSLLHAADDMQLYKYIIKN
TAWQNGKTVTFMPKPLFGDNGSGMHCHQSLWKDGAPLMYDETGYAGLSDT
ARHYIGGLLHHAPSLLAFTNPTVNSYKRLVPGYEAPINLVYSQRNRSACV
RIPITGSNPKAKRLEFRSPDSSGNPYLAFSAMLMAGLDGIKNKIEPQAPV
DKDLYELPPEEAASIPQTPTQLSDVIDRLEADHEYLTEGGVFTNDLIETW
ISFKRENEIEPVNIRPHPYEFALYYDV
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain1htq Chain T Residue 470 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1htq Multicopy crystallographic refinement of a relaxed glutamine synthetase from Mycobacterium tuberculosis highlights flexible loops in the enzymatic mechanism and its regulation.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		E129 H269 E357 R359
Binding residue
(residue number reindexed from 1)		E132 H275 E365 R367
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D50 E129 E131 E212 E220 H269 R339 E357 R359
Catalytic site (residue number reindexed from 1) D53 E132 E134 E218 E226 H275 R346 E365 R367
Enzyme Commision number 6.3.1.2: glutamine synthetase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0001968 fibronectin binding
GO:0003824 catalytic activity
GO:0004356 glutamine synthetase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0035375 zymogen binding
GO:0046872 metal ion binding
Biological Process
GO:0006542 glutamine biosynthetic process
GO:0010756 positive regulation of plasminogen activation
GO:0019740 nitrogen utilization
GO:0051260 protein homooligomerization
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1htq, PDBe:1htq, PDBj:1htq
PDBsum1htq
PubMed12146952
UniProtP9WN39|GLN1B_MYCTU Glutamine synthetase (Gene Name=glnA1)

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