Structure of PDB 8k2a Chain Sk Binding Site BS01

Receptor Information
>8k2a Chain Sk (length=256) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALPPRTEKMAVDQDWPSVYPVAAPFKPSAVPLPVRMGYPVKKGVPMAKEG
NLELLKIPNFLHLTPVAIKKHCEALKDFCTEWPAALDSDEKCEKHFPIEI
DSTDYVSSGPSVRNPRARVVVLRVKLSSLNLDDHAKKKLIKLVGERYCKT
TDVLTIKTDRCPLRRQNYDYAVYLLTVLYHESWNTEEWEKSKTEADMEEY
IWENSSSERNILETLLQMKKEIEEYKKSVVSLKNEEENENSISQYKESVK
RLLNVT
Ligand information
>8k2a Chain S1 (length=928) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugc
aagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaaca
agcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacc
cccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaac
uaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggu
cacacgauuaacccaagucaauagaaccggcguaaagaguguuuuagauc
acaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaa
aauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaaga
cccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacag
uucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaa
aggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucg
auaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccau
cuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacgua
aagacguuaggucaagguguagcccaugagguggcaagaaaugggcuaca
uuuucuaccccagaaacgauagcccuuaugaaauaagggucgaaggugga
uuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagc
gcguacacaccgcccgucacccuccucaaguauacuucaaaggacaauua
acuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaa
guguacuggaaagugcacuuggacgaac
..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<....<<<.<<<
..<......>......<<........<<<.<..<<..>>.>..>>>...<
<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<
<....>>>.....>>>>>>.........<<<....<<<<....>>>>..>
>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>))...
....)))..>>>>>..>>.>>>>>>...<<<((.....<<<<..<<<<..
....<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.....
........<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<.
..<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<
<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..
>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<
........>>..........<<<<<<<.......<<.<<<..<<<<<<..
.....<<..<<<<<.....>>>.......>>..>>.....<<<....>>>
.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>...
..<<<<.....>>>>.<....<<<<<<<.....>>>>>>>....>.....
>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>
>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<<....<<.
....>>...>>>.......>>>>>.>>>>>>....>.>>...>.....<<
<<<<<<<....>>>>>>>>>........
Receptor-Ligand Complex Structure
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PDB8k2a Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		Y89 K92
Binding residue
(residue number reindexed from 1)		Y38 K41
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005763 mitochondrial small ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8k2a, PDBe:8k2a, PDBj:8k2a
PDBsum8k2a
PubMed38942792
UniProtP82673|RT35_HUMAN Small ribosomal subunit protein mS35 (Gene Name=MRPS35)

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