Structure of PDB 8bsi Chain Sj Binding Site BS01

Receptor Information
>8bsi Chain Sj (length=64) Species: 5741 (Giardia intestinalis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RALTSAGKVRKCTPKKEKKEKPRPPRGRAYKRLLYNKNFVDDTLIHNGRR
LGPNNLLIRQKLGF
Ligand information
>8bsi Chain St (length=1454) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cauccggucgauccugccggagcgcgacgcucuccccaaggacgaagcca
ugcaugcccgcucacccgggacgcggcggacggcucaggacaacgguugc
accccccgcggcggucccugcuagccggacaccgcuggcaacccggcgcc
aagacgugcgcgcacgggcgcgcgccccgcgggcgagcagcgugacgcag
cgacggcccgcccgggcuuccggggcaucacccggucggcgcggucgcgg
cgcgccgagggcccgacgccuggcggagaaucaggguucgacuccggaga
gcgggccugcgagacggcccgcacauccaaggacggcagcaggcgcggaa
cuugcccaaugcgcggcgcgcgaggcagcgacggggagcgcgcgagcgag
gcgggcccacagcccccgccgcgcagccgagggcaaggucugugccagca
gccgcgguaauuccagcucggcgagcgucgcgcggcgcugcugcaguuga
aacgcccguaguuggccccccgccgccacgaggaaacgggagcgcuccag
gcaggcccguuggccccgccgcgugggaccgcgcagcgggcgcggcgcgc
cgccgccgcagccccgaggagagcgggcgggggcaccgguaccggccggg
gacgggugaaacaggaugaucccgccgagaccgccggccgcgcaggcgcc
ugccaagaccgccucugucaaucaagggcgaaggccgggggcuagaaggc
gaucagacaccaccguauucccggccguaaacggugccgccccgcggccg
gcgcgcgcgucccgccggccgcccagggaaaccgggaggcuccgggcucu
ggggggaguauggccgcaaggcugaaacuugaaggcauugacggaggggu
accaccagacguggagucugcggcucaaucugacucaacgcgcgcaccuc
accaggcccggacgcgcggaggaccgacagccgggcgcgcuuucgcgauc
gcgcgggugguggugcauggccgcucccagcccguggcgcgagccgucug
cuccauugcgacaacgagcgagaccccggccgcgggcgccgcgggacggc
ccgcggcagcgggaggacggcggggcgauagcaggucugugaugcccuca
gacgcccugggccgcacgcgcgcuacacuggcggggccagccggcgcccg
ccaggacgcgcggagcccccgccguggccgggaccgcgggcuggaacgcc
cccgcgcaccaggaaugucuuguaggcgcccgcccccaccgcgcgccgga
cgcgucccugccccuuguacacaccgcccgucgcuccuaccgacugggcg
cggcggcgagcgccccggacgcgcgaagggccgcgagcccccgcgccugg
aggaaggagaagucguaacaagguauccguaggugaaccugcggauggau
ccuu
...<<<<<.[..(((>>>>>.<<<<<<<<<..<<<<<..<......<<<.
<<<..<<<.<<...........>>>>>......<<........<<<..<<
..<<...<<<<<.............<<.....<<<<<<....>>>>>>..
....>>...<....<.<.<<<<...[.[...<.....>..>>>>.>>...
>....>.>>>>..>>>>..>>>.<<<....<<<..<<<<<<<<.......
>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.
<<<<<<..........>>>>>>.<.<<<..>>>.>...>>>>>>......
...<<<....<<<<...>>>>..>>>..>...>>>>>............<
<<<<<.........>>>>>>.....<<<<<<<......[..[.....((.
.>>)).......]..].>>>>>..>>>>>>>>>..........<<<((..
...<<<<...<<<.......<<<.<<<<<<.......<<..<<.......
>>...........>>......>>>>>..>.>>>..<<<<<<.....].].
.>>>..>>>..........<<<<<<<.....<<<<..<<..<<<<<.<<<
..<.<......>.>.....>>>.>>>>.>.>>......<<<....>>>..
>>>>....>>>>.>>>...>>>...>>>>...<<<<<<<<...<...<<.
<.........>.>>...>>>>>>>>>.........<<<.<<..<<<<<<<
<<<.<.....>.>>>>>>>>>>...<<..))>>....>>.....>>>.>>
>.<<<......<<<<....>>>>....>>>..)))..]<<<<<.<<<<<<
<..<<.<<<<<<..<<<.<<<<<<......<<........>>........
.<<<<<......<<<<<<......<<<.<<<.......>>>.>>>....>
>>>>>...<..<<<..<<.<<<<<<....<<.<<<<<<....>>>....<
<......>>....>>>.>>....<<<<..<<<<<<...>>>>>>.....<
<<<<....>>>>>........>>>>....>>>.>>>.....>>>>>.>..
.....>>>>>...>>.>>>>.>>>.....<<<<<<<.......<<<.<<.
...>>.>>>.......>>>>>>>...........<<.<<<<......>>>
>.>>..........>>>>>>....<<<<<.<<.......>>.>>>>>...
...>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<
<<<.<<<..<<<.<<<...........>>>.>>>..>>>.>>>>>>>>..
.>>.>>>>>..>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....
....
Receptor-Ligand Complex Structure
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PDB8bsi Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		S8 G10 K11 V12 R13 C15 T16 K19 K21 K22 K24 R26 R29 G30 R31 R35 K40 P56 N57 N58 L59 R62 F67
Binding residue
(residue number reindexed from 1)		S5 G7 K8 V9 R10 C12 T13 K16 K18 K19 K21 R23 R26 G27 R28 R32 K37 P53 N54 N55 L56 R59 F64
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005829 cytosol
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8bsi, PDBe:8bsi, PDBj:8bsi
PDBsum8bsi
PubMed36912103
UniProtA0A644F843

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