Structure of PDB 8a3w Chain Sh Binding Site BS01

Receptor Information
>8a3w Chain Sh (length=95) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ENSSCVFVSPIFRPSTTKAQVMELFAGVKVQRLRMYRQNFAYAYLDSPAA
AKKFVEEKNGTEFRGHTLRVALSARSLEKLRARQEAANVVIAAHR
Ligand information
>8a3w Chain S1 (length=1663) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcagcaggaaucugcgcauggcucauuaau
cagacguaaucugccgcaaaaaucuugcggcaaaauuggauaacuuggcg
aaacgccaagcuaauacaugaaccaaccgggugucuccgagacgcccagc
gaaugaaugacaaaaccaaugccgcaguaacacccagcaguguugacuca
auucauuccgugcgaaagccggcuuccggcgucuuuugacgaacaacugc
ccuaucagcuggugauggccguguaguggacugccauggcguugacggga
gcgggggauuaggguucgauuccggagagggagccugagaaauagcuacc
acuucuacggagggcagcaggcgcgcaaauugcccaaugucaaaacaaaa
cgaugaggcagcgaaaagaaauagaguuauuucaaugggggauauuuaaa
cccaucccgagacaauuggaggacaagucuggugccagcacccgcgguaa
uuccagcuccaaaagcguauauuaaugcuguugcuguuaaaggguucgua
guugaacugugggcugcagcccgugaaagaaaaacacgggaggggugcau
gucaugcaugccguccgugauuuuuuacugugacuaaagaagcgugacua
aagcagucaugacuugaauuagaaagcaugggauaacaaaggagcuuuuu
aaagguuggagauuauggagcugugcgacaaaugggaaugaaggagggua
guucgggggagaacguacuggggcgucagaggugaaauucuuagaccgca
ccaagacgaacuacagcgaaggcauucuucaaggauaccuuccucaauca
agaaccaaaguguggagaucgaagaugauuagaaaccauuguaguccaca
cugcaaacgaugacacccaugaauuggggauaucuucacguuuucuguuu
uacgcgaaagcuuugagguuacagucucaggggggaguacguucgcaaga
gugaaacuuaaagaaauugacggaauggcaccacaagacguggagcgugc
gguuuaauuugacucaacacggggaacuuuaccagauccggacagggauu
gacagauugaguguucuuucucgauucccugaaugguggugcauggccgc
uuauggucgguggagugauuuguuugguugauuccgucaacggacgagau
ccaagcugcccaguagaauucagaauuauucggaauucuucucugcggga
uuccuuuguagcacaaggugaaauuuugggcaacagcaggucugugaugc
uccucaauguucugggcgacacgcgcacuacaaugucagugagaacaaga
acuacuugaucaaaagaguggggaaaccccggaaucacauagacccacuu
gggaccgaggauugcaauuauuggucgcgcaacgaggaaugucucguagg
cgcagcucaucaaacugugccgauuacgucccugccauuuguacacaccg
cccgucguuguuuccgaugauggugcaauacaggugaucggacgaaaguu
caccgauauuucuucaauagaggaagcaagucguaacaagguagcuguag
gaccugcagcugg
...<<<<<.{.((((>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<....<<<<.>>>>...>>.>>......<<..<....
<<<..<<..<<...<<.<<.....<<<<.>>>>...<<.....<<<<<<.
....>>>>>>......>>..........<<<<<<<<<.>>>>>>>>>.<<
<<<<<<<<.....((.{..{<<.>>.........................
>>>>>>>>...>>....<<<<<...>>>>>...>>.>>..>>>>..>>>.
<<<....<<<....<<<<<.<<.......>>.>>>>>>>>......>>>.
.<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>>
.<<<<....>>>>...>>>>>>.........<<<....<<<.........
.>>>..>>>..>....>>>....<<<....>>>.....<<<<........
....>>>>.......<<<<<((....<.<<<<.....<<..))>>.....
..>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<<<<...
<<<..<....<........>...........<..............<<<<
.......>>>>.........>...<<<<<<<<.......<<...<.....
..>..<<<..>>>.....>>......>>>>>..>>>..........<<.<
<.<<...}..}.))......>>.>>.>>..........>......<<<<<
..<<...<<<<<<<<..<<<<.<<<...<<<......>>>......>>>.
>>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>....>>>..
.>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>
>>.........<<<.<<...<<<<.<<<<<<.<....>.>>>>>>.>>>>
...<<..]]>>.....>>.....>>>.>>>.<<<......<<<<....>>
>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<<
<<<......<<........>>..........<<<<<.<....<<<<....
<<.<<<........>>>.>>.......>>>>...<<.<<<..<<.<<<<<
<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<
<<<<.<<<<.....<<<<<<<.<<<<.>>>>.>>>>>>>.....>>>>..
..<<<<........>>>>.......>>>>>....>>>.>>>.....>>>>
>>>.....>.>>>>>...>>.>>>>>.>>.....<<<.<<<.......<.
..<.<.<..........>.>.>....>........>>>...>>>......
<....<<<..<..........>..>>>.....>.....>>>>>>....<<
<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.....
..<<.<.<<<<<<<<..<<.<<<.<.<<<<..<<<<<.<........>.>
>>>>..>>>>.>.>>>.>>..>>>>>>>>>.>>.........<<<<<<<<
<.>>>>>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8a3w CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : WILD TYPE
Resolution2.89 Å
Binding residue
(original residue number in PDB)		P142 R145 P146 S147 Q152 R166 M167 R169 Q170 N171 F172 H198 S205 R207 I223 H226
Binding residue
(residue number reindexed from 1)		P10 R13 P14 S15 Q20 R34 M35 R37 Q38 N39 F40 H66 S73 R75 I91 H94
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8a3w, PDBe:8a3w, PDBj:8a3w
PDBsum8a3w
PubMed
UniProtQ4Q5K7

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