Structure of PDB 8g60 Chain Sf Binding Site BS01

Receptor Information
>8g60 Chain Sf (length=63) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVFMASHFDR
HYCGKCCLTYCFN
Ligand information
>8g60 Chain S2 (length=1654) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucccacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccgggggaugcgugcau
uuaucaguggugacucuagauaaccucgggccgaucgcacgccccccgug
gcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguaguc
gccgugccuaccauggugaccacgggugacggggaaucaggguucgauuc
cggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggc
gcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaa
uacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaaucc
uuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaa
uuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucgua
guuggaucuuguuacuuugaaaaaauuagaguguucaaagcaggcccgag
ccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauu
uuguugguuuucggaacugaggccaugauuaagagggacggccgggggca
uucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggac
cagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagu
cggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgau
gccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuc
cgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcuga
aacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcu
uaauuugacucaacacgggaaaccucacccggcccggacacggacaggau
ugacagauugauagcucuuucucgauuccgugggugguggugcauggccg
uucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgaga
cucuggcaugcuaacuaguuacgcgacccccgagcggucggcguccccca
acuucuuagagggacaaguggcguucagccacccgagauugagcaauaac
aggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugac
uggcucagcgugugccuacccuacgccggcaggcgcggguaacccguuga
accccauucgugauggggaucggggauugcaauuauuccccaugaacgag
gaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcc
cuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggc
ccucggaucggcccgagcgcugagaagacggucgaacuugacuaucuaga
ggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggauc
auua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<.........<<.....<<.<<....
...>>.>>......>>.........<<<<...<<...>>...>>>><<..
<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>
>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<..
.......>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>
>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>
.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<
<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<..........
.>..>>.........<<<<<((....<.<<<<.....<<..))>>.....
..>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...
<<<.<<.....<<<<<<.<.......<<...<.......>.<<<<.....
..>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...
............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<
..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>...
....<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<
<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........
<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>..
.<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>..
..>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<..
.....<<........>>..........<<<<<.<....<<<<<<......
.<<.<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<.<<<<
<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....
<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>
>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>
.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<.
<<<........<.......<<<.<<<<....>>>>.>>>....>......
...>>>.>>......<.....<<<<<..........>>>>>.....>...
..>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>
>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<
<.<<...<<<<<......>>>>>...>>.>>>>..>>>.>>>>>>>>...
>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>.....
....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8g60 mRNA decoding in human is kinetically and structurally distinct from bacteria.
Resolution2.54 Å
Binding residue
(original residue number in PDB)		K89 K90 N91 K92 H93 K94 R95 K97 Y105 R118 F131 M132 A133 S134 H135 F136 R138 Y140 G142
Binding residue
(residue number reindexed from 1)		K1 K2 N3 K4 H5 K6 R7 K9 Y17 R30 F43 M44 A45 S46 H47 F48 R50 Y52 G54
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0031386 protein tag activity
GO:0031625 ubiquitin protein ligase binding
GO:0046872 metal ion binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0016567 protein ubiquitination
GO:0019941 modification-dependent protein catabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0030666 endocytic vesicle membrane
GO:0031982 vesicle
GO:0032040 small-subunit processome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8g60, PDBe:8g60, PDBj:8g60
PDBsum8g60
PubMed37020024
UniProtP62979|RS27A_HUMAN Ubiquitin-ribosomal protein eS31 fusion protein (Gene Name=RPS27A)

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