Structure of PDB 8rxx Chain Se Binding Site BS01

Receptor Information
>8rxx Chain Se (length=58) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLARAGKVKNQTPKVAKQEKPKQPRGRALKRLKYTRRFLSKTVKPGEKVH
MNKQPPGK
Ligand information
>8rxx Chain S1 (length=1836) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcagcaggaaucugcgcauggcucauuaaa
ucagacguaaucugccgcaaaaaucuugcggccgcaaaauuggauaacuu
ggcgaaacgccaagcuaauacaugaaccaaccggguguucuccacgugag
acgcccagcgaaugaaugacaguaaaaccaaugccuugcaguaacaccca
gcaguguugacucaauucauuccgugcgaaagccggcuuguuccggcguc
uuuugacgaacaacugcccuaucagcuggugauggccguguaguggacug
ccauggcguugacgggagcgggggauuaggguucgauuccggagagggag
ccugagaaauagcuaccacuucuacggagggcagcaggcgcgcaaauugc
ccaaugucaaaacaaaacgaugaggcagcgaaaagaaauagaguuguuug
ucauuucaaugggggauauuuaaacccauccaauaucgaguaacaauugg
aggacaagucuggugccagcacccgcgguaauuccagcuccaaaagcgua
uauuaaugcuguugcuguuaaaggguucguaguugaacugugggcugugc
agggcccuugcagcccgugaaaagaaacaagaaacacgggagugggucgc
augucaugcaugccagggggcguccgugauuuuuacugugacuaaagaag
cgugacuaaagcagucauuugacuugaauuagaaagcaugggauaacaaa
ggagcagccucuaggcuaccguuucggcuuuuguuguuuuuaaaggucua
uuggagauuauggagcuguuucccacggugugacggccucuaggaaugaa
ggaggguaguucgggggagaacguacuggggcgucagaggugaaauucuu
agaccgcaccaagacgaacuacagcgaaggcauucuucaaggauaccuuc
cucaaucaagaaccaaaguguggagaucgaagaugauuagaaaccauugu
aguccacacugcaaacgaugacacccaugaauuggggauacuuaguaucu
uuacgggaauauccucagcacgcacgcgaaagcuuugagguuacagucuc
aggggggaguacguucgcaagagugaaacuuaaagaaauugacggaaugg
caccacaagacguggagcgugcgguuuaauuugacucaacacggggaacu
uuaccagauccggacaggaugagauugacagauugaguguucuuucucga
uucccugaaugguggugcauggccgcuuauggucgguggagugauuuguu
ugguugauuccgucaacggacgagauccaagcugcccaguagaauucaga
auugcccauaggauagcgcauucggucgaauucuucucugcgggauuccu
uuguaauugcacaaggugaaauuuugggcaacagcaggucugugaugcuc
cucaauguucugggcgacacgcgcacuacaaugucagugagaacaagaaa
acgaaccuacuugaucaaaagaguggggaaaccccggaaucacauagacc
cacuugggaccgaggauugcaauuuggucgcgcaacgaggaaugucucgu
aggcgcagcucaucaaacugugccgauuacgucccugccauuuguacaca
ccgcccgucguuguuuccgaugauggugcaauacaggugaucggacaggc
gcccgaaaguucaccgauauuucuucaauagaggaagcaaaagucguaac
aagguagcuguaggggaaccugcagcugggacauuu
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<<<..........<<<
.<<<..<<....<<....<<<<.>>>>...>>.>>......<<.......
.<<<..<<..<<...<<.<<.....<<<<<..>>>>>...<<.....<<<
<<<.....>>>>>>......>>..........<<<<<.<<<<.....>>>
>>>>>>.<<<<<<<<<<.....(((((.((((<<...>>...........
..............>>>>>>>>...>>....<<<<<......>>>>>...
>>.>>..>>>>..>>>.<<<....<<<....<<<<<.<<.......>>.>
>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<.<<
<..........>>>.>>.<<<<....>>>>...>>>>>>.........<<
<....<<<..........>>>..>>>.......>>>....<<<.<<....
.>>.>>>.....<<<<............>>>.....>.........<<<<
<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>
>>>>>.........<<<[[.....<<<<...<<<.......<...<<...
.<..>...>>...>..................<...............<<
<<.......>>>>.............>.....<<<<<<<<.......<<.
..<.......>..<<<....>>>.....>>......>>>>>..>>>....
.......<<..<<<<<<.<<.....>>.<...)))).)))))>.>>>>>>
..>>.......<<<<<<<.<.<<...>>.>...>>>.>>>>.........
...<<<<<..<<...<<<<<<<<<.<<<<.<<<...<<<......>>>..
....>>>.>>>.>>>>.......<<....>>.>>>>>>..>>.>>>.>>.
...>>>...>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>..
.>>>>>>>>>.........<<<.<<..<<..<<<<<<<........<<..
........>>.>>>>>>>..>>...<<..]]>>.....>>.....>>>.>
>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<
<<..<<.<<<<<<..<<.<<<<<<<......<<........>>.......
...<<<<<.<....<<<<........<<.<<<........>>>.>>....
...>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...
<<<......>>>...>>.>>>....<<<<<.<<<<.....<<<<<<<.<<
<<.................>>>>....>>>>>>>.....>>>>....<<<
<.<<......>>>>>>.......>>>>>....>>>.>>>.....>>>>>>
>.....>.>>>>>...>>.>>>>>.>>.....<<<.<<<<......<...
.....<<<<<<<........>>>>>>>....>.......>>>>...>>>.
..........<<<..<........>..>>>...........>>>>>>...
.<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>..
..<..<<.<.<<<<<<<<..<<.<<<.<.<<<<..<<<<<.....<.<<.
.>>.>.....>>>>>..>>>>.>.>>>.>>..>>>>>>>>..>.>>...>
.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8rxx Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.97 Å
Binding residue
(original residue number in PDB)		R10 A11 K13 V14 K15 Q17 T18 V21 K23 Q24 K28 R31 G32 R33 R37 R43 M57 N58 Q60 P61 G63 K64
Binding residue
(residue number reindexed from 1)		R4 A5 K7 V8 K9 Q11 T12 V15 K17 Q18 K22 R25 G26 R27 R31 R37 M51 N52 Q54 P55 G57 K58
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005829 cytosol
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8rxx, PDBe:8rxx, PDBj:8rxx
PDBsum8rxx
PubMed38722744
UniProtQ4Q7P0

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