Structure of PDB 8bsj Chain Sd Binding Site BS01

Receptor Information
>8bsj Chain Sd (length=97) Species: 5741 (Giardia intestinalis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PVKRRNNGRSKYNCGHTNIVRCQNCHRCVPKDKVIKRFTIRNIVDNTIAD
DVLNACVIQGFAIPKLYNKVQYCVSCSIHNHIVRVRSREDRKIRTPP
Ligand information
>8bsj Chain St (length=1454) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cauccggucgauccugccggagcgcgacgcucuccccaaggacgaagcca
ugcaugcccgcucacccgggacgcggcggacggcucaggacaacgguugc
accccccgcggcggucccugcuagccggacaccgcuggcaacccggcgcc
aagacgugcgcgcacgggcgcgcgccccgcgggcgagcagcgugacgcag
cgacggcccgcccgggcuuccggggcaucacccggucggcgcggucgcgg
cgcgccgagggcccgacgccuggcggagaaucaggguucgacuccggaga
gcgggccugcgagacggcccgcacauccaaggacggcagcaggcgcggaa
cuugcccaaugcgcggcgcgcgaggcagcgacggggagcgcgcgagcgag
gcgggcccacagcccccgccgcgcagccgagggcaaggucugugccagca
gccgcgguaauuccagcucggcgagcgucgcgcggcgcugcugcaguuga
aacgcccguaguuggccccccgccgccacgaggaaacgggagcgcuccag
gcaggcccguuggccccgccgcgugggaccgcgcagcgggcgcggcgcgc
cgccgccgcagccccgaggagagcgggcgggggcaccgguaccggccggg
gacgggugaaacaggaugaucccgccgagaccgccggccgcgcaggcgcc
ugccaagaccgccucugucaaucaagggcgaaggccgggggcuagaaggc
gaucagacaccaccguauucccggccguaaacggugccgccccgcggccg
gcgcgcgcgucccgccggccgcccagggaaaccgggaggcuccgggcucu
ggggggaguauggccgcaaggcugaaacuugaaggcauugacggaggggu
accaccagacguggagucugcggcucaaucugacucaacgcgcgcaccuc
accaggcccggacgcgcggaggaccgacagccgggcgcgcuuucgcgauc
gcgcgggugguggugcauggccgcucccagcccguggcgcgagccgucug
cuccauugcgacaacgagcgagaccccggccgcgggcgccgcgggacggc
ccgcggcagcgggaggacggcggggcgauagcaggucugugaugcccuca
gacgcccugggccgcacgcgcgcuacacuggcggggccagccggcgcccg
ccaggacgcgcggagcccccgccguggccgggaccgcgggcuggaacgcc
cccgcgcaccaggaaugucuuguaggcgcccgcccccaccgcgcgccgga
cgcgucccugccccuuguacacaccgcccgucgcuccuaccgacugggcg
cggcggcgagcgccccggacgcgcgaagggccgcgagcccccgcgccugg
aggaaggagaagucguaacaagguauccguaggugaaccugcggauggau
ccuu
...<<<<<.[..(((>>>>>.<<<<<<<<<..<<<<..........<<<.
<<<..<<<.<<...........>>>>>......<<........<<<..<<
..<<...<<<<..............<<.....<<<<<......>>>>>..
....>>........<.<.<<<<...[.[...<.....>..>>>>.>>...
.......>>>>..>>>>..>>>.<<<....<<<..<<<<<<<<.......
>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.
<<<<<<..........>>>>>>.<.<<....>>.>...>>>>>>......
...<<<....<<<<...>>>>..>>>.......>>>>............<
<<<<<.........>>>>>>.....<<<<<<<......[........((.
.>>))..........].>>>>>..>>>>>>>>>..........<<<((..
...<<<<...<<<.......<<<.<<<<<<.......<<..<<.......
>>...........>>......>>>>>..>.>>>..<<<<<<.....].].
.>>>..>>>..........<<<<<<<.....<<<<..<<..<<<<<.<<<
..<.<......>.>.....>>>.>>>>.>.>>......<<<....>>>..
>>>>....>>>>.>>>...>>>...>>>>...<<<<<<<<...<...<<.
<.........>.>>...>>>>>>>>>.........<<<.<<..<<<<<<<
<<<.........>>>>>>>>>>...<<..))>>....>>.....>>>.>>
>.<<<......<<<<....>>>>....>>>..)))..]<<<<<.<<<<<<
<..<<.<<<<<<..<<<.<<<<........<<........>>........
.<<<<<.<....<<<<<<......<<<.<<<.......>>>.>>>....>
>>>>>...<<.<<<..<<.<<<<<<....<<.<<<<<<....>>>....<
........>....>>>.>>....<<<<..<<<<<<...>>>>>>.....<
<<<<....>>>>>........>>>>....>>>.>>>.....>>>>>>>..
...>.>>>>>......>>>>.>>>.....<<<<<<<.......<<<.<<.
...>>.>>>.......>>>>>>>...........<<.<<<<......>>>
>.>>..........>>>>>>....<<<<<.<<.......>>.>>>>>...
...>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<
<<<.<<<..<<<.<<<...........>>>.>>>..>>>.>>>>>>>>..
.>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....
....
Receptor-Ligand Complex Structure
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PDB8bsj Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis.
Resolution6.49 Å
Binding residue
(original residue number in PDB)		P2 V3 K4 R5 R6 N7 N8 G9 R10 K12 Y13 N14 C15 H17 N19 K32 K34 K37 R38 F39 K70 V75 S76 I79 H80 H82 V86 R87 S88 R89 R92 K93 R95 P97 P98
Binding residue
(residue number reindexed from 1)		P1 V2 K3 R4 R5 N6 N7 G8 R9 K11 Y12 N13 C14 H16 N18 K31 K33 K36 R37 F38 K69 V74 S75 I78 H79 H81 V85 R86 S87 R88 R91 K92 R94 P96 P97
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8bsj, PDBe:8bsj, PDBj:8bsj
PDBsum8bsj
PubMed36912103
UniProtA8BQZ7

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