Structure of PDB 8glp Chain Sc Binding Site BS01

Receptor Information
>8glp Chain Sc (length=65) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRVQPIKLARVTKVLGRTGSQGQCTQVRVEFMDDTSRSIIRNVKGPVREG
DVLTLLESEREARRL
Ligand information
>8glp Chain S2 (length=1672) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgccacuuggauaacuguggua
auucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggg
augcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcac
gccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuuc
gaugguagucgccgugccuaccauggugaccacgggugacggggaaucag
gguucgauuccggagagggagccugagaaacggcuaccacauccaaggaa
ggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacga
aaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucca
cuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagca
gccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaa
aaagcucguaguuggaucuuuuuacuuugaaaaaauuagaguguucaaag
caggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccg
cgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacg
gccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcg
caagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaa
gaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgac
cauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgcc
gggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguu
gcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggagugga
gccugcggcuuaauuugacucaacacgggaaaccucacccggcccggaca
cggacaggauugacagauugauagcucuuucucgauuccguggguggugg
ugcauggccguucuuaguugguggagcgauuugucugguuaauuccgaua
acgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucg
gcgucccccaacuucuuagagggacaaguggcguucagccacccgagauu
gagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcg
cuacacugacuggcucagcgugugccuacccuacgccggcaggcgcgggu
aacccguugaaccccauucgugauggggaucggggauugcaauuauuccc
caugaacgaggaauucccaguaagugcgggucauaagcuugcguugauua
agucccugcccuuuguacacaccgcccgucgcuacuaccgauuggauggu
uuagugaggcccucggaucggccccgccggcggagcgcugagaagacggu
cgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguagg
ugaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<..........<<.....<<.<<<..
...>>>.>>......>>.........<<<<...<<<<<<....>>>>>>.
..>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<
<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<...
.<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<...
.>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.
>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>
.>.....<<<<<<<<<.<<<....>.>>.>>>>>.>>>>......<<..<
...........>..>>.........<<<<<((......<<<<.....<<.
.))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((..
...<.<<...<<<.<<.....<<<<<<.<.......<<...<.......>
.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.
<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<
..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>
>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...
>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>
..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>
>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<
....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<
<<.<<<<........<<........>>..........<<<<<.<....<<
<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<
<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...
>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.
>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........
>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>
>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>.
...>.........>>>.>>............<<<<<..........>>>>
>...........>>>>>.....<<<<<<<<.......>>>>>>>>.....
.>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<
<.<<<..<<<<.<<...<<<<<.<<<<..>>>>...>>>>>...>>.>>>
>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<
<..>>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8glp mRNA decoding in human is kinetically and structurally distinct from bacteria.
Resolution1.67 Å
Binding residue
(original residue number in PDB)		R20 S23 Q24 G25 P49
Binding residue
(residue number reindexed from 1)		R17 S20 Q21 G22 P46
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8glp, PDBe:8glp, PDBj:8glp
PDBsum8glp
PubMed37020024
UniProtP62857|RS28_HUMAN Small ribosomal subunit protein eS28 (Gene Name=RPS28)

[Back to BioLiP]