Structure of PDB 8g5z Chain Sc Binding Site BS01

Receptor Information
>8g5z Chain Sc (length=64) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RVQPIKLARVTKVLGRTGSQGQCTQVRVEFMDDTSRSIIRNVKGPVREGD
VLTLLESEREARRL
Ligand information
>8g5z Chain S2 (length=1701) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgccacuuggauaacuguggua
auucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggg
augcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcac
gccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuuc
gaugguagucgccgugccuaccauggugaccacgggugacggggaaucag
gguucgauuccggagagggagccugagaaacggcuaccacauccaaggaa
ggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacga
aaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucca
cuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagca
gccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaa
aaagcucguaguuggaucuugggagcgggcguccccgccuuuacuuugaa
aaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuag
gaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugag
gccaugauuaagagggacggccgggggcauucguauugcgccgcuagagg
ugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaa
gaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucag
auaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggc
guuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggg
uuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaa
gggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaa
accucacccggcccggacacggacaggauugacagauugauagcucuuuc
ucgauuccgugggugguggugcauggccguucuuaguugguggagcgauu
ugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguua
cgcgacccccgagcggucggcgucccccaacuucuuagagggacaagugg
cguucagccacccgagauugagcaauaacaggucugugaugcccuuagau
guccggggcugcacgcgcgcuacacugacuggcucagcgugugccuaccc
uacgccggcaggcgcggguaacccguugaaccccauucgugauggggauc
ggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggu
cauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucg
cuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggg
gugcccuggcggagcgcugagaagacggucgaacuugacuaucuagagga
aguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu
a
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<..........<<.....<<.<<<..
...>>>.>>......>>.........<<<<...<<<<<......>>>>>.
..>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<
<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<...
.<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<...
.>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.
>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>
.>.....<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<
...........>..>>.........<<<<<((....<.<<<<.....<<.
.))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((..
...<.<<...<<<.<<........................<<<<<<.<..
.....<<...<.......>.<<<<.......>>>>...>>......>.>>
>..>>>........<.<<.<<<<<<<...............>>>>>>>.>
>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<.
.....>>>......>>>>>>>>..>>.......<<....>>...>>>>..
>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<...
..>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.
<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>
>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<
<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>....
......<<<<<......<<<<<<.......<<.<<<........>>>.>>
.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>
>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<
<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<
<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>....
..>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<
<.<<<<....>>>>.>>>....>.........>>>.>>............
<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.
......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.
.<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<...
.......>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.
>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........
.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8g5z mRNA decoding in human is kinetically and structurally distinct from bacteria.
Resolution2.64 Å
Binding residue
(original residue number in PDB)		R20 S23 Q24 G25 P49
Binding residue
(residue number reindexed from 1)		R16 S19 Q20 G21 P45
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8g5z, PDBe:8g5z, PDBj:8g5z
PDBsum8g5z
PubMed37020024
UniProtP62857|RS28_HUMAN Small ribosomal subunit protein eS28 (Gene Name=RPS28)

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