Structure of PDB 8a98 Chain Sc Binding Site BS01

Receptor Information
>8a98 Chain Sc (length=84) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GFFDADLSYPTVRTERMKHKRRRLVQGPNSYFMDVSCPRCRQVTVVYSHA
TTSVECKGCSKKLCRPTGGKALLVEGCGYRRKPD
Ligand information
>8a98 Chain S1 (length=1727) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcaugcaggaaucugcgcauggcucauuac
aucagacguaaucugccgcaaaaaucuugcggccgcaaaauuggauaacu
uggcgaaacgccaagcuaauacaugaaccaaccgggugucuccacugaga
cgcccagcgaaugaaugacaguaaaaccaaugccugcaguaacacccagc
aguguugacucaauucauuccgcgaaagccggcuuccggcgucuuuugac
gaacaacugcccuaucagcuggugauggccguguaguggacugccauggc
guugacgggagcgggggauuaggguucgauuccggagagggagccugaga
aauagcuaccacuucuacggagggcagcaggcgcgcaaauugcccaaugu
caaaacaaaacgaugaggcagcgaaaagaaauagaguuguuucaaugggg
gauauuuaaacccaucccgaguaacaauuggaggacaagucuggugccag
cacccgcgguaauuccagcuccaaaagcguauauuaaugcuguugcuguu
aaaggguucguaguugaacugugggcuggcccuugcagcccgugaaagaa
acaagaaacacgggagugguugcaugucaugcaugccguccgugauuuuu
uacugugacuaaagaagcgugacuaaagcagucaugacuugaauuagaaa
gcaugggauaacaaaggagcuuuuuaaagguauuggagauuauggagcug
ugcgacaaaugcuuucuaggaaugaaggaggguaguucgggggagaacgu
acuggggcgucagaggugaaauucuuagaccgcaccaagacgaacuacag
cgaaggcauucuucaaggauaccuuccucaaucaagaaccaaagugugga
gaucgaagaugauuagagaccauuguaguccacacugcaaacgaugacac
ccaugaauuggggauaucuugcacguuuucuguuuucacgcgaaagcuuu
gagguuacagucucaggggggaguacguucgcaagagugaaacuuaaaga
aauugacggaauggcaccacaagacguggagcgugcgguuuaauuugacu
caacacggggaacuuuaccagauccggacaggaugaggauugacagauug
aguguucuuucucgauucccugaaugguggugcauggccgcuuuuggucg
guggagugauuuguuugguugauuccgucaacggacgagauccaagcugc
ccaguagauuucagaauuuuucgggaauucuucucugcgggauuccuuug
uaugcacaaggugaaauuuugggcaacagcaggucugugaugcuccucaa
uguucugggcgacacgcgcacuacaaugucagugagaacaagaacgaacc
uacuugaucaaaagaguggggaaaccccggaaucacauagacccacuugg
gaccgaggauugcaauuauuggucgcgcaacgaggaaugucucguaggcg
cagcucaucaaacugugccgauuacgucccugccauuuguacacaccgcc
cgucguuguuuccgaugauggugcaauacaggugaucggacaggcgaaag
uucaccgauauuucuucaauagaggaagcaaaagucguaacaagguagcu
guaggugaaccugcagcuggaucauuu
...<<<<<.{.((((>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<.....<......>....>>.>>......<<......
..<<<..<<..<<...<<.<<.....<<<<<..>>>>>...<<.....<<
<<<<.....>>>>>>......>>..........<<<<<<<<<....>>>>
>>>>>.<<<<<<<<<<.....((.((.{..{<<..>>.............
............>>>>>>>>.>>....<<<<<...>>>>>...>>.>>..
>>>>..>>>.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>
......>>>..<<<<<<<<....>>>>...>>>>.>>.<<.<<<......
....>>>.>>.<<<<<..>>>>>...>>>>>>.........<<<....<<
<..........>>>..>>>..>....>>>....<<<....>>>.....<<
<<............>>>>.........<<<<<((....<.<<<<.....<
<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[
.....<<<<...<<<.......<...<.......>...>...........
.....<...............<<<<.......>>>>.........>...<
<<<<<<<.......<<...<.......>..<<<..>>>.....>>.....
.>>>>>..>>>..........<<.<<.<<.<...}..}.)).))>..>>.
>>.>>........................<<<<<..<<...<<<<<<<<.
.<<<<.<<<...<<<......>>>......>>>.>>>.>.>>.......<
<....>>.>>>>>>...>>>>>.>>....>>>...>>>>...<<<<<<<<
...<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<.<
<...<<<<.<<<<<<.<.<.>.>.>>>>>>.>>>>....<<..]]>>...
..>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))
).}<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<<<<<......<<...
.....>>..........<<<<<......<<<<.........<<.<<<...
.....>>>.>>.......>>>>.<.<<.<<<..<<.<<<<<<....<<<.
<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<<<
.....<<<.<<<.<<<...>>>..>>>.>>>.....>>>>....<<<<..
.......>>>>.......>>>>>....>>>.>>>.....>>>>>>>>...
...>>>>>...>>.>>>>>.>>.....<<<.<<<.......<......<<
<<<<<........>>>>>>>....>........>>>...>>>......<.
...<<<..<..........>..>>>.....>.....>>>>>>....<<<<
<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..
<<.<.<<<<<<<<..<<.<<<.<.<<<<..<<<<<.<............>
.>>>>>..>>>>.>.>>>.>>..>>>>>>>>..>.>>...>.....<<<<
<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8a98 CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT
Resolution2.46 Å
Binding residue
(original residue number in PDB)		M18 K21 R22 R23 Q27 P29 N30 S31 Y48 H50 T52 T68 G69 G70 K71
Binding residue
(residue number reindexed from 1)		M17 K20 R21 R22 Q26 P28 N29 S30 Y47 H49 T51 T67 G68 G69 K70
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8a98, PDBe:8a98, PDBj:8a98
PDBsum8a98
PubMed38722744
UniProtQ4Q140

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