Structure of PDB 6xa1 Chain Sc Binding Site BS01

Receptor Information
>6xa1 Chain Sc (length=61) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PIKLARVTKVLGRTGSQGQCTQVRVEFMDDTSRSIIRNVKGPVREGDVLT
LLESEREARRL
Ligand information
>6xa1 Chain S2 (length=1590) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggcuacagugaaacugcgaauggcucauuaa
aucaguuaugguuccuuuggucgcucgcacuuggauaacugugguaauuc
uagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugc
gugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccc
uggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguag
ucgccgugccuaccauggugaccacgggugacggggaaucaggguucgau
uccggagagggagccugagaaacggcuaccacauccaaggaaggcagcag
gcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaac
aauacaggaccuguaauuggaaugaguccacuuuaaauccuuuaacgagg
auccauuggagggcaagucuggugccagcagccgcgguaauuccagcucc
aauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuu
uuuacuuugaaaaaauuagaguguucaaagcaggcccgccuggauaccgc
agcuaggaauaauggaauaggaccgcgugaggccaugauuaagagggacg
gccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcg
caagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaa
gaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgac
cauaaacgaugccgaccggcgaugcggcggcguuauugacccgccgggca
gcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaa
gcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccug
cggcuuaauuugacucaacacgggaaaccucacccggcccggacacggac
aggauugacagauugauagcucuuucucgauuccgugggugguggugcau
ggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaa
cgagacucuggcaugcuaacuaguuacgcgacccagcggucggcguaacu
ucuuagagggacaaguggcguucagccacccgagauugagcaauaacagg
ucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacugg
cucagcguguccuacgccggcaggcgcggguaacccguugaaccccauuc
gugauggggaucggggauugcaauuauuccccaugaacgaggaauuccca
guaagugcgggucauaagcuugcguugauuaagucccugcccuuuguaca
caccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggauc
ggccgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucg
uaacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.
<<<..<<....<<....<<.......>>...>>.>>......<<......
..<<<.<....<<....<<<<<.........<<.....<<.<<<.....>
>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>
>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.
.>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<
.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>...
.>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>
>>.........<<<....<<<<...>>>>..>>>......>>.>.....<
<<<<<<<<.>>>>>>.>>>......<<..<...........>..>>....
.....<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>
>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....
.<<<<<<.<.......<<...<.......>.<<<<..>>>>...>>....
..>.>>>..>>>........<.<<.<..>.>>.>....>>....<<<<<<
..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>
>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...
>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>
..........<<<.<<.<<<..<.<<<<<<.<<<<.>>>>>>>>>>.>..
>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......
>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<
<<........<<........>>..........<<<<<......<<<<<<.
......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<
.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>
>....<<<...<...<<<<..<<<<<<<<<<<<....>>>>.>>>>>>>>
..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>
>.....>>>>>>>.......>>>>>......>>>>.>>>.....<<.<<<
........<.<<<.<<<<....>>>>.>>>....>.........>>>.>>
......<.....<<<<<..........>>>>>.....>.....>>>>>..
...<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>
....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<
<<<.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>
...>.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
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PDB6xa1 Selective inhibition of human translation termination by a drug-like compound.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R20 S23 Q24 G25 P49
Binding residue
(residue number reindexed from 1)		R13 S16 Q17 G18 P42
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xa1, PDBe:6xa1, PDBj:6xa1
PDBsum6xa1
PubMed33009412
UniProtP62857|RS28_HUMAN Small ribosomal subunit protein eS28 (Gene Name=RPS28)

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