Structure of PDB 8a98 Chain Sb Binding Site BS01

Receptor Information
>8a98 Chain Sb (length=100) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TTKRRNHGRSKPAHSRGRVKPIHCFNCGRLTPKDKAVGRFVVRRMLDAAS
ARDVAEASPVYGANFPMPRLYMKQRFCIACAIHSRTVRARPVGNRKIRYT
Ligand information
>8a98 Chain S1 (length=1727) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcaugcaggaaucugcgcauggcucauuac
aucagacguaaucugccgcaaaaaucuugcggccgcaaaauuggauaacu
uggcgaaacgccaagcuaauacaugaaccaaccgggugucuccacugaga
cgcccagcgaaugaaugacaguaaaaccaaugccugcaguaacacccagc
aguguugacucaauucauuccgcgaaagccggcuuccggcgucuuuugac
gaacaacugcccuaucagcuggugauggccguguaguggacugccauggc
guugacgggagcgggggauuaggguucgauuccggagagggagccugaga
aauagcuaccacuucuacggagggcagcaggcgcgcaaauugcccaaugu
caaaacaaaacgaugaggcagcgaaaagaaauagaguuguuucaaugggg
gauauuuaaacccaucccgaguaacaauuggaggacaagucuggugccag
cacccgcgguaauuccagcuccaaaagcguauauuaaugcuguugcuguu
aaaggguucguaguugaacugugggcuggcccuugcagcccgugaaagaa
acaagaaacacgggagugguugcaugucaugcaugccguccgugauuuuu
uacugugacuaaagaagcgugacuaaagcagucaugacuugaauuagaaa
gcaugggauaacaaaggagcuuuuuaaagguauuggagauuauggagcug
ugcgacaaaugcuuucuaggaaugaaggaggguaguucgggggagaacgu
acuggggcgucagaggugaaauucuuagaccgcaccaagacgaacuacag
cgaaggcauucuucaaggauaccuuccucaaucaagaaccaaagugugga
gaucgaagaugauuagagaccauuguaguccacacugcaaacgaugacac
ccaugaauuggggauaucuugcacguuuucuguuuucacgcgaaagcuuu
gagguuacagucucaggggggaguacguucgcaagagugaaacuuaaaga
aauugacggaauggcaccacaagacguggagcgugcgguuuaauuugacu
caacacggggaacuuuaccagauccggacaggaugaggauugacagauug
aguguucuuucucgauucccugaaugguggugcauggccgcuuuuggucg
guggagugauuuguuugguugauuccgucaacggacgagauccaagcugc
ccaguagauuucagaauuuuucgggaauucuucucugcgggauuccuuug
uaugcacaaggugaaauuuugggcaacagcaggucugugaugcuccucaa
uguucugggcgacacgcgcacuacaaugucagugagaacaagaacgaacc
uacuugaucaaaagaguggggaaaccccggaaucacauagacccacuugg
gaccgaggauugcaauuauuggucgcgcaacgaggaaugucucguaggcg
cagcucaucaaacugugccgauuacgucccugccauuuguacacaccgcc
cgucguuguuuccgaugauggugcaauacaggugaucggacaggcgaaag
uucaccgauauuucuucaauagaggaagcaaaagucguaacaagguagcu
guaggugaaccugcagcuggaucauuu
...<<<<<.{.((((>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<.....<......>....>>.>>......<<......
..<<<..<<..<<...<<.<<.....<<<<<..>>>>>...<<.....<<
<<<<.....>>>>>>......>>..........<<<<<<<<<....>>>>
>>>>>.<<<<<<<<<<.....((.((.{..{<<..>>.............
............>>>>>>>>.>>....<<<<<...>>>>>...>>.>>..
>>>>..>>>.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>
......>>>..<<<<<<<<....>>>>...>>>>.>>.<<.<<<......
....>>>.>>.<<<<<..>>>>>...>>>>>>.........<<<....<<
<..........>>>..>>>..>....>>>....<<<....>>>.....<<
<<............>>>>.........<<<<<((....<.<<<<.....<
<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[
.....<<<<...<<<.......<...<.......>...>...........
.....<...............<<<<.......>>>>.........>...<
<<<<<<<.......<<...<.......>..<<<..>>>.....>>.....
.>>>>>..>>>..........<<.<<.<<.<...}..}.)).))>..>>.
>>.>>........................<<<<<..<<...<<<<<<<<.
.<<<<.<<<...<<<......>>>......>>>.>>>.>.>>.......<
<....>>.>>>>>>...>>>>>.>>....>>>...>>>>...<<<<<<<<
...<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<.<
<...<<<<.<<<<<<.<.<.>.>.>>>>>>.>>>>....<<..]]>>...
..>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))
).}<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<<<<<......<<...
.....>>..........<<<<<......<<<<.........<<.<<<...
.....>>>.>>.......>>>>.<.<<.<<<..<<.<<<<<<....<<<.
<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<<<
.....<<<.<<<.<<<...>>>..>>>.>>>.....>>>>....<<<<..
.......>>>>.......>>>>>....>>>.>>>.....>>>>>>>>...
...>>>>>...>>.>>>>>.>>.....<<<.<<<.......<......<<
<<<<<........>>>>>>>....>........>>>...>>>......<.
...<<<..<..........>..>>>.....>.....>>>>>>....<<<<
<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..
<<.<.<<<<<<<<..<<.<<<.<.<<<<..<<<<<.<............>
.>>>>>..>>>>.>.>>>.>>..>>>>>>>>..>.>>...>.....<<<<
<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
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PDB8a98 CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT
Resolution2.46 Å
Binding residue
(original residue number in PDB)		T2 T3 K4 R5 R6 N7 H8 G9 R10 P13 H15 R17 G18 R19 R30 K34 K36 R40 F41 K74 R76 I79 R86 V88 R89 R91 P92 V93 R96 K97 R99 Y100 T101
Binding residue
(residue number reindexed from 1)		T1 T2 K3 R4 R5 N6 H7 G8 R9 P12 H14 R16 G17 R18 R29 K33 K35 R39 F40 K73 R75 I78 R85 V87 R88 R90 P91 V92 R95 K96 R98 Y99 T100
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8a98, PDBe:8a98, PDBj:8a98
PDBsum8a98
PubMed38722744
UniProtQ4Q8L6

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