Structure of PDB 6y0g Chain Sb Binding Site BS01

Receptor Information

>6y0g Chain Sb (length=83) Species: 9606 (Homo sapiens)

PLAKDLLHPSPEEEKRKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQ
TVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQH

Ligand information

>6y0g Chain S2 (length=1697)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaau
ucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggau
gcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgc
ccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugg
uagucgccgugccuaccauggugaccacgggugacggggaaucaggguuc
gauuccggagagggagccugagaaacggcuaccacauccaaggaaggcag
caggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaau
aacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuua
aauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgc
gguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagc
ucguaguuggaucuugggaggccucucggcgcccgaagcauuuacuuuga
aaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcua
ggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacuga
ggccaugauuaagagggacggccgggggcauucguauugcgccgcuagag
gugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugcca
agaauguuuucauuaaucaagaacgaaagucggagguucgaagacgauca
gauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcgg
cguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuugg
guuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacgga
agggcaccaccaggaguggagccugcggcuuaauuugacucaacacggga
aaccucacccggcccggacacggacaggauugacagauugauagcucuuu
cucgauuccgugggugguggugcauggccguucuuaguugguggagcgau
uugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguu
acgcgacccccgagcggucgcgucccccaacuucuuagagggacaagugg
cguucagccacccgagauugagcaauaacaggucugugaugcccuuagau
guccggggcugcacgcgcgcuacacugacuggcucagcgugugccuaccc
uacgccggcaggcgcggguaacccguugaaccccauucgugauggggauc
ggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggu
cauaagcuugcguugauuagucccugcccuuuguacacaccgcccgucgc
uacuaccgauuggaugguuuagugaggcccucggaucggccccgccgggg
ccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaagua
aaagucguaacaagguuuccguaggugaaccugcggaaggaucauua

...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<......<<....<<<<<........<<.....<<.<<<....
.>>>.>>......>>.........<<<<...<<<<<......>>>>>...
>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<
<...>>>>>>>>.>>.>>>...>>....>>>.<<<....<<<....<<<<
<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>
....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>
>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>...
..<<.<<<<<<............>>.>>>>..>>.......<..<.....
......>..>..........<<<<<((....<.<<<<.....<<..))>>
.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.
<<...<<<.<<..............................<<<<<<.<.
......<<...<.......>.<<<<.......>>>>...>>......>.>
>>..>>>........<.<<.<<<<<<<...............>>>>>>>.
>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<
......>>>......>>>>>>>>..>>.......<<....>>...>>>>.
.>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<..
...>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<
.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>
>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<
<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>...
.......<<<<<.<....<<<<<<.......<<.<<<........>>>.>
>.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>
>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<
<<<<<<<<.......>>>>>>>>.....>>>>..>>>>..>.....<<<<
<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>....
>.>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<
<.<<<<....>>>>.>>>....>.........>>>.>>......<...<.
<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.
......>>>>>>>>.....>>...>>>>>>>>>>.>>....<..<<.<..
<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<....<<<<...
.>.>>>......>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>
...>.>>...>.....<<<<<<<<<....>>>>>>>>>.........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6y0g Dynamics of uS19 C-Terminal Tail during the Translation Elongation Cycle in Human Ribosomes.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): R17 K18 K20 K21 K22 P28 S30 F47 H49 Q51 P66 T67 G68 G69 K70 R72 E75
• Binding residue (residue number reindexed from 1): R16 K17 K19 K20 K21 P27 S29 F46 H48 Q50 P65 T66 G67 G68 K69 R71 E74

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0002181 cytoplasmic translation
• GO:0006364 rRNA processing
• GO:0006412 translation
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0014069 postsynaptic density
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0032040 small-subunit processome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6y0g, PDBe:6y0g, PDBj:6y0g
• PDBsum: 6y0g
• PubMed: 32268098
• UniProt: P42677|RS27_HUMAN Small ribosomal subunit protein eS27 (Gene Name=RPS27)