Structure of PDB 6xa1 Chain Sb Binding Site BS01

Receptor Information
>6xa1 Chain Sb (length=82) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PLAKDLLHPSPEEEKRKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQ
TVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQ
Ligand information
>6xa1 Chain S2 (length=1590) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggcuacagugaaacugcgaauggcucauuaa
aucaguuaugguuccuuuggucgcucgcacuuggauaacugugguaauuc
uagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugc
gugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccc
uggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguag
ucgccgugccuaccauggugaccacgggugacggggaaucaggguucgau
uccggagagggagccugagaaacggcuaccacauccaaggaaggcagcag
gcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaac
aauacaggaccuguaauuggaaugaguccacuuuaaauccuuuaacgagg
auccauuggagggcaagucuggugccagcagccgcgguaauuccagcucc
aauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuu
uuuacuuugaaaaaauuagaguguucaaagcaggcccgccuggauaccgc
agcuaggaauaauggaauaggaccgcgugaggccaugauuaagagggacg
gccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcg
caagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaa
gaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgac
cauaaacgaugccgaccggcgaugcggcggcguuauugacccgccgggca
gcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaa
gcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccug
cggcuuaauuugacucaacacgggaaaccucacccggcccggacacggac
aggauugacagauugauagcucuuucucgauuccgugggugguggugcau
ggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaa
cgagacucuggcaugcuaacuaguuacgcgacccagcggucggcguaacu
ucuuagagggacaaguggcguucagccacccgagauugagcaauaacagg
ucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacugg
cucagcguguccuacgccggcaggcgcggguaacccguugaaccccauuc
gugauggggaucggggauugcaauuauuccccaugaacgaggaauuccca
guaagugcgggucauaagcuugcguugauuaagucccugcccuuuguaca
caccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggauc
ggccgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucg
uaacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.
<<<..<<....<<....<<.......>>...>>.>>......<<......
..<<<.<....<<....<<<<<.........<<.....<<.<<<.....>
>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>
>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.
.>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<
.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>...
.>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>
>>.........<<<....<<<<...>>>>..>>>......>>.>.....<
<<<<<<<<.>>>>>>.>>>......<<..<...........>..>>....
.....<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>
>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....
.<<<<<<.<.......<<...<.......>.<<<<..>>>>...>>....
..>.>>>..>>>........<.<<.<..>.>>.>....>>....<<<<<<
..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>
>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...
>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>
..........<<<.<<.<<<..<.<<<<<<.<<<<.>>>>>>>>>>.>..
>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......
>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<
<<........<<........>>..........<<<<<......<<<<<<.
......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<
.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>
>....<<<...<...<<<<..<<<<<<<<<<<<....>>>>.>>>>>>>>
..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>
>.....>>>>>>>.......>>>>>......>>>>.>>>.....<<.<<<
........<.<<<.<<<<....>>>>.>>>....>.........>>>.>>
......<.....<<<<<..........>>>>>.....>.....>>>>>..
...<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>
....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<
<<<.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>
...>.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6xa1 Selective inhibition of human translation termination by a drug-like compound.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R17 K20 K21 K22 P28 S30 F47 H49 Q51 P66 T67 G68 G69 K70 R72
Binding residue
(residue number reindexed from 1)		R16 K19 K20 K21 P27 S29 F46 H48 Q50 P65 T66 G67 G68 K69 R71
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0014069 postsynaptic density
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6xa1, PDBe:6xa1, PDBj:6xa1
PDBsum6xa1
PubMed33009412
UniProtP42677|RS27_HUMAN Small ribosomal subunit protein eS27 (Gene Name=RPS27)

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