Structure of PDB 8rxx Chain Sa Binding Site BS01

Receptor Information
>8rxx Chain Sa (length=72) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EALQNAVMFDKETYDKLRSEVPKYKLITPSIISDRLKIAVSIAAAGLKQL
CREKLIRLVSCSSKTRVYTRIV
Ligand information
>8rxx Chain S1 (length=1836) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcagcaggaaucugcgcauggcucauuaaa
ucagacguaaucugccgcaaaaaucuugcggccgcaaaauuggauaacuu
ggcgaaacgccaagcuaauacaugaaccaaccggguguucuccacgugag
acgcccagcgaaugaaugacaguaaaaccaaugccuugcaguaacaccca
gcaguguugacucaauucauuccgugcgaaagccggcuuguuccggcguc
uuuugacgaacaacugcccuaucagcuggugauggccguguaguggacug
ccauggcguugacgggagcgggggauuaggguucgauuccggagagggag
ccugagaaauagcuaccacuucuacggagggcagcaggcgcgcaaauugc
ccaaugucaaaacaaaacgaugaggcagcgaaaagaaauagaguuguuug
ucauuucaaugggggauauuuaaacccauccaauaucgaguaacaauugg
aggacaagucuggugccagcacccgcgguaauuccagcuccaaaagcgua
uauuaaugcuguugcuguuaaaggguucguaguugaacugugggcugugc
agggcccuugcagcccgugaaaagaaacaagaaacacgggagugggucgc
augucaugcaugccagggggcguccgugauuuuuacugugacuaaagaag
cgugacuaaagcagucauuugacuugaauuagaaagcaugggauaacaaa
ggagcagccucuaggcuaccguuucggcuuuuguuguuuuuaaaggucua
uuggagauuauggagcuguuucccacggugugacggccucuaggaaugaa
ggaggguaguucgggggagaacguacuggggcgucagaggugaaauucuu
agaccgcaccaagacgaacuacagcgaaggcauucuucaaggauaccuuc
cucaaucaagaaccaaaguguggagaucgaagaugauuagaaaccauugu
aguccacacugcaaacgaugacacccaugaauuggggauacuuaguaucu
uuacgggaauauccucagcacgcacgcgaaagcuuugagguuacagucuc
aggggggaguacguucgcaagagugaaacuuaaagaaauugacggaaugg
caccacaagacguggagcgugcgguuuaauuugacucaacacggggaacu
uuaccagauccggacaggaugagauugacagauugaguguucuuucucga
uucccugaaugguggugcauggccgcuuauggucgguggagugauuuguu
ugguugauuccgucaacggacgagauccaagcugcccaguagaauucaga
auugcccauaggauagcgcauucggucgaauucuucucugcgggauuccu
uuguaauugcacaaggugaaauuuugggcaacagcaggucugugaugcuc
cucaauguucugggcgacacgcgcacuacaaugucagugagaacaagaaa
acgaaccuacuugaucaaaagaguggggaaaccccggaaucacauagacc
cacuugggaccgaggauugcaauuuggucgcgcaacgaggaaugucucgu
aggcgcagcucaucaaacugugccgauuacgucccugccauuuguacaca
ccgcccgucguuguuuccgaugauggugcaauacaggugaucggacaggc
gcccgaaaguucaccgauauuucuucaauagaggaagcaaaagucguaac
aagguagcuguaggggaaccugcagcugggacauuu
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<<<..........<<<
.<<<..<<....<<....<<<<.>>>>...>>.>>......<<.......
.<<<..<<..<<...<<.<<.....<<<<<..>>>>>...<<.....<<<
<<<.....>>>>>>......>>..........<<<<<.<<<<.....>>>
>>>>>>.<<<<<<<<<<.....(((((.((((<<...>>...........
..............>>>>>>>>...>>....<<<<<......>>>>>...
>>.>>..>>>>..>>>.<<<....<<<....<<<<<.<<.......>>.>
>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<.<<
<..........>>>.>>.<<<<....>>>>...>>>>>>.........<<
<....<<<..........>>>..>>>.......>>>....<<<.<<....
.>>.>>>.....<<<<............>>>.....>.........<<<<
<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>
>>>>>.........<<<[[.....<<<<...<<<.......<...<<...
.<..>...>>...>..................<...............<<
<<.......>>>>.............>.....<<<<<<<<.......<<.
..<.......>..<<<....>>>.....>>......>>>>>..>>>....
.......<<..<<<<<<.<<.....>>.<...)))).)))))>.>>>>>>
..>>.......<<<<<<<.<.<<...>>.>...>>>.>>>>.........
...<<<<<..<<...<<<<<<<<<.<<<<.<<<...<<<......>>>..
....>>>.>>>.>>>>.......<<....>>.>>>>>>..>>.>>>.>>.
...>>>...>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>..
.>>>>>>>>>.........<<<.<<..<<..<<<<<<<........<<..
........>>.>>>>>>>..>>...<<..]]>>.....>>.....>>>.>
>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<
<<..<<.<<<<<<..<<.<<<<<<<......<<........>>.......
...<<<<<.<....<<<<........<<.<<<........>>>.>>....
...>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...
<<<......>>>...>>.>>>....<<<<<.<<<<.....<<<<<<<.<<
<<.................>>>>....>>>>>>>.....>>>>....<<<
<.<<......>>>>>>.......>>>>>....>>>.>>>.....>>>>>>
>.....>.>>>>>...>>.>>>>>.>>.....<<<.<<<<......<...
.....<<<<<<<........>>>>>>>....>.......>>>>...>>>.
..........<<<..<........>..>>>...........>>>>>>...
.<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>..
..<..<<.<.<<<<<<<<..<<.<<<.<.<<<<..<<<<<.....<.<<.
.>>.>.....>>>>>..>>>>.>.>>>.>>..>>>>>>>>..>.>>...>
.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8rxx Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.97 Å
Binding residue
(original residue number in PDB)		L36 N38 V73 S74 K81 C84 R85 C94 S95 S96
Binding residue
(residue number reindexed from 1)		L3 N5 V40 S41 K48 C51 R52 C61 S62 S63
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8rxx, PDBe:8rxx, PDBj:8rxx
PDBsum8rxx
PubMed38722744
UniProtQ4Q9X4

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