Structure of PDB 8ovj Chain SZ Binding Site BS01

Receptor Information
>8ovj Chain SZ (length=127) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FQKKKAEVCIRTSQFKVNKLLNRKQFIVEVNHPHWCGTVPTQLIRKKLAT
LYKVPDASQVSLFGFKTKFGGGKTTGFGLIYDDLASLKRFEPNYRKTRMG
FGKARLPARKSVKERRNRNKKLRGKAK
Ligand information
>8ovj Chain S1 (length=1755) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcagcaggaaucugcgcauggcucauuaaa
ucagacguaaucugccgcaaaaaucuugcggcaaaauuggauaacuuggc
gaaacgccaagcuaauacaugaaccaaccgggugucuccgagacgcccag
cgaaugaaugacaguaaaaccaaugccgcaguaacacccagcaguguuga
cucaauucauucgcgaaagccggcuuccggcgucuuuugacgaacaacug
cccuaucagcuggugauggccguguaguggacugccauggcguugacggg
agcgggggauuaggguucgauuccggagagggagccugagaaauagcuac
cacuucuacggagggcagcaggcgcgcaaauugcccaaugucaaaacaaa
acgaugaggcagcgaaaagaaauagaguuuuucaaugggggauauuuaaa
cccauccaauaucgaguaacaauuggaggacaagucuggugccagcaccc
gcgguaauuccagcuccaaaagcguauauuaaugcuguugcuguuaaagg
guucguaguugaacugugggcucccuugcagcccgugaaagaaaaaacac
gggagugggucgcaugucaugcaugccguccgugauuuuuuacugugacu
aaagaagcgugacuaaagcagucaugacuugaauuagaaagcaugggaua
acaaaggagcuuuuuaaagguuggagauuauggagcugugcgacaaaugc
uuucccaucucggugugggguuuacggccucuaggaaugaaggaggguag
uucgggggagaacguacuggggcgucagaggugaaauucuuagaccgcac
caagacgaacuacagcgaaggcauucuucaaggauaccuuccucaaucaa
gaaccaaaguguggagaucgaagaugauuagaaaccauuguaguccacac
ugcaaacgaugacacccaugaauuggggauaucuucacguuuucuguuuu
uuacgcgaaagcuuugagguuacagucucaggggggaguacguucgcaag
agugaaacuuaaagaaauugacggaauggcaccacaagacguggagcgug
cgguuuaauuugacucaacacggggaacuuuaccagauccggacaggaug
aggauugacagauugaguguucuuucucgauucccugaaugguggugcau
ggccgcuuauggucgguggagugauuuguuugguugauuccgucaacgga
cgagauccaagcugcccaguagaauucagaauugcccauaggauagcgca
uucggaauucuucucugcgggauuccuuuguagcacaaggugaaauuuug
ggcaacagcaggucugugaugcuccucaauguucugggcgacacgcgcac
uacaaugucagugagaacaagaacuacuugaucaaaagaguggggaaacc
ccggaaucacauagacccacuugggaccgaggauugcaauuauuggucgc
gcaacgaggaaugucucguaggcgcagcucaucaaacugugccgauuacg
ucccugccauuuguacacaccgcccgucguuguuuccgaugauggugcaa
uacaggugaucggacagggcccgaaaguucaccgauauuucuucaauaga
ggaagcaaaagucguaacaagguagcuguaggggaaccugcagcugggac
auuuu
...<<<<<.{.((((>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<....<<<<.>>>>...>>.>>......<<.......
.<<<..<<..<<...<<.<<.....<<<<.>>>>...<<.....<<<<<<
.....>>>>>>......>>..........<<<<<<<<<.>>>>>>>>>.<
<<<<<<<<<.....((.((.{..{<<.>>.....................
....>>>>>>>>>>....<<<<<...>>>>>...>>.>>..>>>>..>>>
.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>......>>>
..<<<<<<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>
>.<<<<<..>>>>>...>>>>>>.........<<<....<<<........
..>>>..>>>..>....>>>....<<<...>>>.....<<<<........
....>>>.....>.........<<<<<((....<.<<<<.....<<..))
>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....
<<<<...<<<.......<.............>............<.....
...........<<<<.......>>>>.........>...<<<<<<<<...
....<<...<.......>..<<<..>>>.....>>......>>>>>..>>
>..........<<.<<.<<...}..}.)).))...>>.>>.>>.......
.......<...<.<....>.>....>..................<<<<<.
.<<...<<<<<<<<..<<<<.<<<...<<<......>>>......>>>.>
>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>....>>>...
>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>
>.........<<<.<<.<.<...<<<<<<...........>>>>>>...>
.>..<<..]]>>.....>>.....>>>.>>>.<<<......<<<<....>
>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<
<<<<......<<........>>..........<<<<<.<....<<<<...
......<<.<<<........>>>.>>.......>>>>.<.<<.<<<..<<
.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>
>....<<<<<.<<<<.....<<<<<<<.<<<<.................>
>>>.>>>>>>>.....>>>>....<<<<........>>>>.......>>>
>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>>.>
>.....<<<.<<<.......<..<<.<.<..........>.>.>>...>.
.......>>>...>>>......<....<<<..<..........>..>>>.
....>.....>>>>>>....<<<<<<<.........>>>>>>>......>
>...>>>>>>>>>>.>>....<..<<.<.<<<<<<<<..<<.<<<.<.<<
<<..<<<<<.<...<.<...>.>...>.>>>>>..>>>>.>.>>>.>>..
>>>>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.....
.....
Receptor-Ligand Complex Structure
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PDB8ovj Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.4 Å
Binding residue
(original residue number in PDB)
K5 K6 A8 T14 S15 Q16 F17 W37 C38 G39 T40 T43 Y54 F67 T69 F71 G72 G73 R91 Y96 R100 K105 A106 R107 L108 R111 K115 E116 R118 N119 K123 R125 G126 K127 K129
Binding residue
(residue number reindexed from 1)
K3 K4 A6 T12 S13 Q14 F15 W35 C36 G37 T38 T41 Y52 F65 T67 F69 G70 G71 R89 Y94 R98 K103 A104 R105 L106 R109 K113 E114 R116 N117 K121 R123 G124 K125 K127
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8ovj, PDBe:8ovj, PDBj:8ovj
PDBsum8ovj
PubMed38722744
UniProtQ4Q1D2

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