Structure of PDB 8g60 Chain SZ Binding Site BS01

Receptor Information
>8g60 Chain SZ (length=84) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKKWSKGKVRDKLNNLVLFDKATYDKLCKEVPNYKLITPAVVSERLKIRG
SLARAALQELLSKGLIKLVSKHRAQVIYTRNTKG
Ligand information
>8g60 Chain S2 (length=1654) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucccacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccgggggaugcgugcau
uuaucaguggugacucuagauaaccucgggccgaucgcacgccccccgug
gcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguaguc
gccgugccuaccauggugaccacgggugacggggaaucaggguucgauuc
cggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggc
gcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaa
uacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaaucc
uuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaa
uuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucgua
guuggaucuuguuacuuugaaaaaauuagaguguucaaagcaggcccgag
ccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauu
uuguugguuuucggaacugaggccaugauuaagagggacggccgggggca
uucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggac
cagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagu
cggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgau
gccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuc
cgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcuga
aacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcu
uaauuugacucaacacgggaaaccucacccggcccggacacggacaggau
ugacagauugauagcucuuucucgauuccgugggugguggugcauggccg
uucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgaga
cucuggcaugcuaacuaguuacgcgacccccgagcggucggcguccccca
acuucuuagagggacaaguggcguucagccacccgagauugagcaauaac
aggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugac
uggcucagcgugugccuacccuacgccggcaggcgcggguaacccguuga
accccauucgugauggggaucggggauugcaauuauuccccaugaacgag
gaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcc
cuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggc
ccucggaucggcccgagcgcugagaagacggucgaacuugacuaucuaga
ggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggauc
auua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<.........<<.....<<.<<....
...>>.>>......>>.........<<<<...<<...>>...>>>><<..
<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>
>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<..
.......>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>
>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>
.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<
<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<..........
.>..>>.........<<<<<((....<.<<<<.....<<..))>>.....
..>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...
<<<.<<.....<<<<<<.<.......<<...<.......>.<<<<.....
..>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...
............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<
..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>...
....<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<
<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........
<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>..
.<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>..
..>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<..
.....<<........>>..........<<<<<.<....<<<<<<......
.<<.<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<.<<<<
<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....
<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>
>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>
.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<.
<<<........<.......<<<.<<<<....>>>>.>>>....>......
...>>>.>>......<.....<<<<<..........>>>>>.....>...
..>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>
>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<
<.<<...<<<<<......>>>>>...>>.>>>>..>>>.>>>>>>>>...
>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>.....
....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8g60 mRNA decoding in human is kinetically and structurally distinct from bacteria.
Resolution2.54 Å
Binding residue
(original residue number in PDB)		W35 S36 K43 L44 N46 R80 G81 S82 R85 K102 H103 R104
Binding residue
(residue number reindexed from 1)		W4 S5 K12 L13 N15 R49 G50 S51 R54 K71 H72 R73
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0014069 postsynaptic density
GO:0015935 small ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8g60, PDBe:8g60, PDBj:8g60
PDBsum8g60
PubMed37020024
UniProtP62851|RS25_HUMAN Small ribosomal subunit protein eS25 (Gene Name=RPS25)

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