Structure of PDB 7cpv Chain SZ Binding Site BS01

Receptor Information

>7cpv Chain SZ (length=72) Species: 10090 (Mus musculus)

DKLNNLVLFDKATYDKLCKEVPNYKLITPAVVSERLKIRGSLARAALQEL
LSKGLIKLVSKHRAQVIYTRNT

Ligand information

>7cpv Chain S2 (length=1637)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucacuuggauaacugugguaauu
cuagagcuaauacaugccgacgggcgcauuuaucaguggugacucuagau
aaccgccgaucgcacgcccuggcggcgacgacccauucgaacgucugccc
uaucaacuuucgaugguagucgccgugccuaccauggugaccacggguga
cggggaaucaggguucgauuccggagagggagccugagaaacggcuacca
cauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccgggga
gguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauug
gaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaaguc
uggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguu
gcugcaguuaaaaagcucguaguuggaucuucucgaagcguuuacuuuga
aaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcua
ggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacuga
ggccaugauuaagagggacggccgggggcauucguauugcgccgcuagag
gugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugcca
agaauguuuucauuaaucaagaacgaaagucggagguucgaagacgauca
gauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcgg
cguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuugg
guuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacgga
agggcaccaccaggaguggagccugcggcuuaauuugacucaacacggga
aaccucacccggcccggacacggacaggauugacagauugauagcucuuu
cucgauuccgugggugguggugcauggccguucuuaguugguggagcgau
uugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguu
acgcgacccccgagcggucggcguaacuucuuagagggacaaguggcguu
cagccacccgagauugagcaauaacaggucugugaugcccuuagaugucc
ggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccugcg
ccggcaggcgcggguaacccguugaaccccauucgugauggggaucgggg
auugcaauuauuccccaugaacgaggaauucccaguaagugcgggucaua
agcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuac
uaccgauuggaugguuuagugaggcccucggaucggccccgccggcggag
cgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaa
caagguuuccguaggugaaccugcggaaggaucauua

...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<......<<....<<<.........<<.....<<..<......
.>..>>......>>...........<<..<<<<<...<......>..>>>
>>..>>...<<<<.<<<<..>>>>>>>>....>>>...>>....>>>.<<
<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...
<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.
<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..
>>>..>...>>.>.....<<..<<<<<............>>.>>>...>>
......<<..<...........>..>>.........<<<<<((......<
<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.....
....<.<((.....<.<<...<<<.<<...<.....>....<<<<<<.<.
......<<...<.......>..<<<.......>>>....>>......>.>
>>..>>>........<.<<.<<..<<................>>...>>.
>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<
......>>>......>>>>>>>>..>>.......<<....>>...>>>>.
.>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<..
...>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<
.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>
>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<
<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>...
.......<<<<<.<....<<<<<<.......<<.<<<........>>>.>
>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>
>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<
<<<<<<<<.......>>>>.>>>>>>>>..>>>>..>.....<<<<<...
..>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>
>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<<<<
<<....>>>>>>>>....>.........>>>.>>......<.....<<<<
<..........>>>>>.....>.....>>>>>.....<<<<<<<<.....
..>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<
<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<....<..>.....
.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...
>.....<<<<<<<<<<..>>>>>>>>>>.........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7cpv A male germ-cell-specific ribosome controls male fertility.
• Resolution: 3.03 Å
• Binding residue (original residue number in PDB): L44 R80 S82 R85 K102 H103 R104
• Binding residue (residue number reindexed from 1): L3 R39 S41 R44 K61 H62 R63

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006364 rRNA processing
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0014069 postsynaptic density
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0045202 synapse
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7cpv, PDBe:7cpv, PDBj:7cpv
• PDBsum: 7cpv
• PubMed: 36517592
• UniProt: P62852|RS25_MOUSE Small ribosomal subunit protein eS25 (Gene Name=Rps25)