Structure of PDB 6lqs Chain SZ Binding Site BS01

Receptor Information

>6lqs Chain SZ (length=123) Species: 559292 (Saccharomyces cerevisiae S288C)

AVTIRTRKVISNPLLARKQFVVDVLHPNRANVSKDELREKLAEVYKAEKD
AVSVFGFRTQFGGGKSVGFGLVYNSVAEAKKFEPTYRLVRYGLAEKVEKA
SRQQRKQKKNRDKKIFGTGKRLA

Ligand information

>6lqs Chain SA (length=1249)

aagauaguuaucugguugauccugccaguagucauaugcuugucucaaag
ccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaaucagu
uaucguuuauuugauagcaugguauaacugugguaauucuagagcuaaua
caugcuaaucucgacccuuuggaagagauguauuuauuagagucuucgga
cucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggc
gaugguucauucaaauuucugcccuaucaacuuucgaugguaggauagug
gccuaccaugguuucaacggggcaggcgcgcaaauuacccaauccuaauu
cagggagguagugacaauaaauaacgauacagggcccauucgggucuugu
aauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggc
aagucuggugccagcagccgcgguaauuccagcuccaauagcguauauug
cucguaguugaacuuugggcccgguuggccgguccggauuuccaacgggg
ccuuuccuuuuuacuuugaaaaaauuagaguguucaaagcaggcguauug
cucgaauauauuagcauggaauaauagaauagguugguucuauuucuagg
accugauuaauagggacggucgggggcaucaguauucaauugucagaggu
gaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaag
gacguuuucauuaaucaagaacguagggaucgggugguguuuuuuuaaug
acccacucggcaccuugggggaguauggucgcaaggcugaaacuuaaagg
aauugacggaagggcaccaccaggaguggagccugcggcucaacacgggg
aaacucaccagguccagacacaauaaggauugacauucuugauuuugugg
gugguggugcauugaugcccuuguucugggcccgcgcgcuacacugacgg
agccagcgaguaacuccgucgugcugacgaggaauuccuaguaagcgcaa
gucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgu
cgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagaga
agggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuu
agaggaacuaaaaggguuuccguaggugaaccugcggaaggaucauuaa

..............................<..<<<<<<...<......<
<<.<<<..<<....<<....<<..........>>...>>.>>....<<<.
.<<..<<....<<<.......<<....<<.<<<.....>>>.>>.....>
>......<<<<<..<<....>>..>>>>><...<<<<<<..<<<<..>>>
>....<<......>>>>>>>>.....>...<<<<..<<<.....>>>.>>
>>....>>>...>>>>..>>>..<<....<<.....<<<<<<<<......
.>>>>>>>>.>>......>>.>>>>>>.........<<<....<<<....
.>>>..>>>.........>.....<<<<<<<..<<<<....>>>>..>>>
>.>>>......<<..<...........>..>>.........<<<<<<...
....<<<....>>>..................>>>>>>..>>>>>>.>.<
.<<...<<<.<<.....<<<<<.<<<<<..<.<...>.>..>>>>>.>>>
>>........<<<<<.<<............<.......>...<<.....>
>.............>>.>>..>>>..........<..<...<..>..>..
>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<..
....>>>......>.>>>>>>..>>.......<<....>>...>>>>..>
.>>>>.>>>...>>>...>>.>..<<<..<<<<<<<<.<<<........>
>>>>>>>>>>..>>>.....................<<.........>>.
....<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<<.............
.........<<<......<<<<<.....................>>>>>.
......<<........>>......>>>.....>>>>.>>>.....<<<<<
<<...........>>>>>>>.............>>>>>>....<<<<<<<
<.......>>>>>>>>......>>...>>>>>>>............>>>>
>..<<<<.<<....<.<<<<.<..<<..<.<<......<<...<<.....
.<<<<....>>>>......>>...>>......>>.>..>>..>.>>>>>.
...>>.>>>>.......<<<<<<<<<....>>>>>>>>>..........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6lqs Cryo-EM structure of 90 S small ribosomal subunit precursors in transition states.
• Resolution: 3.8 Å
• Binding residue (original residue number in PDB): A33 N34 K37 F58 F60 R61 T62 Q63 F64 G65 G66 K84 Y89 R93 S104 R105 Q106 K109 Q110 K112 N113 K116 K117 F119 T121
• Binding residue (residue number reindexed from 1): A30 N31 K34 F55 F57 R58 T59 Q60 F61 G62 G63 K81 Y86 R90 S101 R102 Q103 K106 Q107 K109 N110 K113 K114 F116 T118

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6lqs, PDBe:6lqs, PDBj:6lqs
• PDBsum: 6lqs
• PubMed: 32943522
• UniProt: P0CX31|RS24A_YEAST Small ribosomal subunit protein eS24A (Gene Name=RPS24A)