Structure of PDB 8g6j Chain SY Binding Site BS01

Receptor Information
>8g6j Chain SY (length=131) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NDTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTT
PDVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKK
TSRKQRKERKNRMKKVRGTAKANVGAGKKPK
Ligand information
>8g6j Chain S2 (length=1701) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgccacuuggauaacuguggua
auucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggg
augcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcac
gccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuuc
gaugguagucgccgugccuaccauggugaccacgggugacggggaaucag
gguucgauuccggagagggagccugagaaacggcuaccacauccaaggaa
ggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacga
aaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucca
cuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagca
gccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaa
aaagcucguaguuggaucuugggagcgggcguccccgccuuuacuuugaa
aaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuag
gaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugag
gccaugauuaagagggacggccgggggcauucguauugcgccgcuagagg
ugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaa
gaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucag
auaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggc
guuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggg
uuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaa
gggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaa
accucacccggcccggacacggacaggauugacagauugauagcucuuuc
ucgauuccgugggugguggugcauggccguucuuaguugguggagcgauu
ugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguua
cgcgacccccgagcggucggcgucccccaacuucuuagagggacaagugg
cguucagccacccgagauugagcaauaacaggucugugaugcccuuagau
guccggggcugcacgcgcgcuacacugacuggcucagcgugugccuaccc
uacgccggcaggcgcggguaacccguugaaccccauucgugauggggauc
ggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggu
cauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucg
cuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggg
gugcccuggcggagcgcugagaagacggucgaacuugacuaucuagagga
aguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu
a
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<..........<<.....<<.<<<..
...>>>.>>......>>.........<<<<...<<<<<......>>>>>.
..>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<
<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<...
.<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<...
.>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.
>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>
.>.....<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<
...........>..>>.........<<<<<((....<.<<<<.....<<.
.))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((..
...<.<<...<<<.<<........................<<<<<<.<..
.....<<...<.......>.<<<<.......>>>>...>>......>.>>
>..>>>........<.<<.<<<<<<<...............>>>>>>>.>
>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<.
.....>>>......>>>>>>>>..>>.......<<....>>...>>>>..
>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<...
..>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.
<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>
>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<
<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>....
......<<<<<......<<<<<<.......<<.<<<........>>>.>>
.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>
>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<
<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<
<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>....
..>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<
<.<<<<....>>>>.>>>....>.........>>>.>>............
<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.
......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.
.<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<...
.......>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.
>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........
.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8g6j mRNA decoding in human is kinetically and structurally distinct from bacteria.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		K11 F12 K32 A33 T34 P36 K37 G59 F60 R61 T62 H63 F64 G65 G66 H89 R93 R104 K105 R107 K108 E109 K111 N112 K115 K116 R118 G119 T120 K122
Binding residue
(residue number reindexed from 1)		K10 F11 K31 A32 T33 P35 K36 G58 F59 R60 T61 H62 F63 G64 G65 H88 R92 R103 K104 R106 K107 E108 K110 N111 K114 K115 R117 G118 T119 K121
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0031369 translation initiation factor binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0034101 erythrocyte homeostasis
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0044391 ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8g6j, PDBe:8g6j, PDBj:8g6j
PDBsum8g6j
PubMed37020024
UniProtP62847|RS24_HUMAN Small ribosomal subunit protein eS24 (Gene Name=RPS24)

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