Structure of PDB 7wtq Chain SW Binding Site BS01

Receptor Information

>7wtq Chain SW (length=129) Species: 4932 (Saccharomyces cerevisiae)

TRSSVLADALNAINNAEKTGKRQVLIRPSSKVIIKFLQVMQKHGYIGEFE
YIDDHRSGKIVVQLNGRLNKCGVISPRFNVKIGDIEKWTANLLPARQFGY
VILTTSAGIMDHEEARRKHVSGKILGFVY

Ligand information

>7wtq Chain C2 (length=1255)

uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaaauacagugaaacugcgaauggcucauua
aaucaguuaucguuuauuugauaguuccucuacaugguauaacuguggua
auucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagaugua
uuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaaua
acuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucu
gcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacgg
guaacggggaauaaggguucgauuccggagagggagccugagaaacggcu
accacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauuca
gggagguagugacaauaaauaacgauacagggucuuguaauuggaaugag
uacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugcc
agcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcag
uuaaaaagcucguaguugaacuuugggcccgguuaacggggccuuuccuu
cuggcuaaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcag
gcguauugcucgaauauauuagcauggaauaauagaauaggacguuuggu
ucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucg
ggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaag
acuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaac
gaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccaua
aacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggc
accuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaa
ggcugaaacuuaaagaauugacggaagggcgcccuuuguaccgcccgucg
cuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaag
ggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuag
aggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggau
cauua

...<<<<<.[[[[.{>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<.......>>...>>.>>......<<.....
...<<<..<<..<<....<<<...............<<....<<.<<<..
...>>>.>>.....>>.........<<<<<..<<....>>..>>>>><..
.<<<<<<......(((((((.<<<....>>>..............>>>>>
>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>
>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>
>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>
.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>
>>..>>>..>....>.>.....<<<<<<<<....>>>>>.>>>......<
<..<...........>..>>.........<<<<<........<<<<.<<<
.<<....>>>>>....>>>>.>>>>>..>>>>>>>>>>.........<<<
[[.....<.<<...<<<.<<....<<<<<<.<<..>>.>>>>>>....<<
<<<<.....>>>>>>...<<<<<.<<.......<<...<.......>..<
<<.....>>>....>>......>>.>>..>>>.........<<<..<<<<
<<<<.....))))))).>>>>>>>>.>>>.....>>....<<<<<<.<<.
..<<<<..<<..<<<<<<.<...<<<..(...>>>......>.>>>>>>.
.>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>
....<<<<<<<...<...<<<<..)......>>>>...>>>>>>>>....
......<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>.
.>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....
>>>>....>>>..}]].]]..<<.<<<<<..>>>>>>>.<<<...<<.<.
.<<<<.<<..<<<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<
<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>>>
.>>.>>>>...>.>>......>>><<<<<<<<<....>>>>>>>>>....
.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7wtq The nucleoplasmic phase of pre-40S formation prior to nuclear export.
• Resolution: 3.7 Å
• Binding residue (original residue number in PDB): T2 R3 S4 A8 D9 N12 N16 R28 S31 K32 R57 K71 V74 I75 S76 N80 K82 I83 K88 W89 N92 T105 T106 S107 R118 H120 Y130
• Binding residue (residue number reindexed from 1): T1 R2 S3 A7 D8 N11 N15 R27 S30 K31 R56 K70 V73 I74 S75 N79 K81 I82 K87 W88 N91 T104 T105 S106 R117 H119 Y129

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7wtq, PDBe:7wtq, PDBj:7wtq
• PDBsum: 7wtq
• PubMed: 36321656
• UniProt: P0C0W1|RS22A_YEAST Small ribosomal subunit protein uS8A (Gene Name=RPS22A)