Structure of PDB 8y0w Chain SU Binding Site BS01

Receptor Information
>8y0w Chain SU (length=103) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IHRIRITLTSRNVKSLEKVCADLIRGAKEKNLKVKGPVRMPTKTLRITTR
KTPCGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQITSISIEPGVEVEVTI
ADA
Ligand information
>8y0w Chain S2 (length=1735) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaa
cugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucg
cgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggcc
gaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuau
caacuuucgaugguagucgccgugccuaccauggugaccacgggugacgg
ggaaucaggguucgauuccggagagggagccugagaaacggcuaccacau
ccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggaggu
agugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaa
ugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucugg
ugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcu
gcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgcccuc
ucggccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagc
aggcccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguuc
uauuuuguugguuuucggaacugaggccaugauuaagagggacggccggg
ggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagac
ggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacga
aagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaa
cgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcag
cuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaag
cugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugc
ggcuuaauuugacucaacacgggaaaccucacccggcccggacacggaca
ggauugacagauugauagcucuuucucgauuccgugggugguggugcaug
gccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaac
gagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucc
cccaacuucuuagagggacaaguggcguucagccacccgagauugagcaa
uaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacac
ugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccg
uugaaccccauucgugauggggaucggggauugcaauuauuccccaugaa
cgaggaauucccaguaagugcgggucauaagcuugcguugauuaaguccc
ugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagug
aggcccucggaucggccccgccggggucggcccacggcccuggcggagcg
cugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaaca
agguuuccguaggugaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<..................<<.....
<<.<<<.....>>>.>>......>>.........<<<<...<<<<.....
...>>>>...>>>><<..<<<<<...<......>..>>>>>......>>.
..<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<..
..<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<
.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<
<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>
..>...>>.>.....<<.....<<..<<....>>..>>.......>>...
...<<..<...........>..>>.........<<<<<((....<.<<<<
.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>........
.<.<((.....<.<<...<<<.<<.......................<<.
<.............>>>...<<<<<<.<.......<<...<.......>.
<<<<..>>>>...>>......>.>>>..>>>........<.<<.<<<.<<
<...............>>>.>>>.>>.>....>>....<<<<<<..<...
<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>
>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>..
..<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>......
....<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>
>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>
>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<
<<<......<<........>>..........<<<<<......<<<<<<..
.....<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.
<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>
....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>..
...>>>>..>>>>..>.....<<<<<.....>>>>>........>>>...
.>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>....
.<<.<<<........<.......<<<.<<<<....>>>>.>>>....>..
.......>>>.>>......<...<.<<<<<..........>>>>>>....
>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...
>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<.<<<<<<.<<<.
.<<<<.<<...<<<<<...<<.....................>>.....>
>>>>...>>.>>>>..>>>.>>>>>>.>...>>.>>>>...>.>>...>.
....<<<<<<<<<<..>>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8y0w dormant ribosome with eIF5A, eEF2 and SERBP1
Resolution3.4 Å
Binding residue
(original residue number in PDB)		R19 V29 K30 E33 K49 G52 V54 R55 M56 P57 K67 P69 C70 G71 E72 K75 T76 W77 R79 R83 H85 R87 H92
Binding residue
(residue number reindexed from 1)		R3 V13 K14 E17 K33 G36 V38 R39 M40 P41 K51 P53 C54 G55 E56 K59 T60 W61 R63 R67 H69 R71 H76
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0097371 MDM2/MDM4 family protein binding
GO:1990948 ubiquitin ligase inhibitor activity
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:1901798 positive regulation of signal transduction by p53 class mediator
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8y0w, PDBe:8y0w, PDBj:8y0w
PDBsum8y0w
PubMed38698775
UniProtP60866|RS20_HUMAN Small ribosomal subunit protein uS10 (Gene Name=RPS20)

[Back to BioLiP]