Structure of PDB 7cpu Chain ST Binding Site BS01

Receptor Information
>7cpu Chain ST (length=140) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENW
FYTRAASTARHLYLRGGAGVGSMTKIYGGRQRNGVRPSHFSRGSKSVARR
VLQALEGLKMVEKDQDGGRKLTPQGQRDLDRIAGQVAAAN
Ligand information
>7cpu Chain S2 (length=1656) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucacuuggauaacugugguaauu
cuagagcuaauacaugccgacgggcgcauuuaucaguggugacucuagau
aaccgccgaucgcacgcccuggcggcgacgacccauucgaacgucugccc
uaucaacuuucgaugguagucgccgugccuaccauggugaccacggguga
cggggaaucaggguucgauuccggagagggagccugagaaacggcuacca
cauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccgggga
gguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauug
gaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaaguc
uggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguu
gcugcaguuaaaaagcucguaguuggaucuucucgaagcguuuacuuuga
aaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcua
ggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacuga
ggccaugauuaagagggacggccgggggcauucguauugcgccgcuagag
gugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugcca
agaauguuuucauuaaucaagaacgaaagucggagguucgaagacgauca
gauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcgg
cguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuugg
guuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacgga
agggcaccaccaggaguggagccugcggcuuaauuugacucaacacggga
aaccucacccggcccggacacggacaggauugacagauugauagcucuuu
cucgauuccgugggugguggugcauggccguucuuaguugguggagcgau
uugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguu
acgcgacccccgagcggucggcguaacuucuuagagggacaaguggcguu
cagccacccgagauugagcaauaacaggucugugaugcccuuagaugucc
ggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccugcg
ccggcaggcgcggguaacccguugaaccccauucgugauggggaucgggg
auugcaauuauuccccaugaacgaggaauucccaguaagugcgggucaua
agcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuac
uaccgauuggaugguuuagugaggcccucggaucggccccgccggggucg
gcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucua
gaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaagga
ucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<..<
.....<<<......<<....<<<.........<<.....<<.<<......
.>>.>>......>>...........<<..<<<<<...<......>..>>>
>>..>>...<<<<.<<<<..>>>>>>>>....>>>...>>....>>>.<<
<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...
<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>>.
<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..
>>>..>...>>.>.....<<.<<<<<<............>>.>>>.>.>>
......<<..<...........>..>>.........<<<<<((......<
<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.....
....<.<((.....<.<<...<<<.<<...<.....>....<<<<<<.<.
......<<...<.......>..<<<.......>>>....>>......>.>
>>..>>>........<.<<.<<.........................>>.
>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<
......>>>......>>>>>>>>..>>.......<<....>>...>>>>.
.>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<..
...>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<
.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>
>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<
<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>...
.......<<<<<.<....<<<<<<.......<<.<<<........>>>.>
>.....>>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>
>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<
<<<<<<<<.......>>>>.>>>>>>>>..>>>>..>.....<<<<<...
..>>>>>........>>>....>>>.>>>...>.>>>>>>>.....>.>>
>>>......>>>>.>>>.....<<.<<<........<.......<<<<<<
<<....>>>>>>>>....>.........>>>.>>......<.....<<<<
<..........>>>>>.....>.....>>>>>.....<<<<<<<<.....
..>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<
<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.............
....................>>>>>...>>.>>>>..>>>.>>>>>>>>.
..>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>...
......
Receptor-Ligand Complex Structure
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PDB7cpu A male germ-cell-specific ribosome controls male fertility.
Resolution2.82 Å
Binding residue
(original residue number in PDB)
G3 V4 Q11 Q12 R16 W33 K38 K41 K43 E44 L45 P47 Y48 R56 S59 R62 H63 L66 R67 G71 V72 G73 S74 K77 I78 R82 R84 G86 V87 R88 P89 H91 F92 S96 K97 S98 R101 Q105 G119 G120 R121 P125 Q128 R129 D132
Binding residue
(residue number reindexed from 1)
G1 V2 Q9 Q10 R14 W31 K36 K39 K41 E42 L43 P45 Y46 R54 S57 R60 H61 L64 R65 G69 V70 G71 S72 K75 I76 R80 R82 G84 V85 R86 P87 H89 F90 S94 K95 S96 R99 Q103 G117 G118 R119 P123 Q126 R127 D130
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0007219 Notch signaling pathway
GO:0030218 erythrocyte differentiation
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0045202 synapse
GO:0098794 postsynapse
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7cpu, PDBe:7cpu, PDBj:7cpu
PDBsum7cpu
PubMed36517592
UniProtQ9CZX8|RS19_MOUSE Small ribosomal subunit protein eS19 (Gene Name=Rps19)

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